Development of chitosan/β-glycerophosphate/glycerol hydrogel as a thermosensitive coupling agent

This work develops a dual-function thermosensitive hydrogel to prevent overheating, a side effect of focused ultrasound therapy. The proposed hydrogel has the components of chitosan, β-glycerophosphate, and glycerol. Its thermosensitive sol-to-gel transition gives an instant signal of overheating wi...

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Bibliographic Details
Published in:Carbohydrate polymers 2016-08, Vol.147, p.409-414
Main Authors: Huang, Chih-Ling, Chen, Yu-Bin, Lo, Yu-Lung, Lin, Yi-Hsiang
Format: Article
Language:English
Subjects:
Chitosan
Chitosan - chemistry
Coupling agent
Glycerol
Glycerol - chemistry
Glycerophosphates - chemistry
Hydrogel, Polyethylene Glycol Dimethacrylate
Hydrogels - chemistry
Temperature
Thermosensitive hydrogel
Ultrasonic
Ultrasonic Therapy - instrumentation
β-glycerophosphate
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Summary:This work develops a dual-function thermosensitive hydrogel to prevent overheating, a side effect of focused ultrasound therapy. The proposed hydrogel has the components of chitosan, β-glycerophosphate, and glycerol. Its thermosensitive sol-to-gel transition gives an instant signal of overheating without the need of any awkward sensing device. Impacts of varying component concentrations on the sol-to-gel temperature, rate, and degree of transparency are also investigated. Chemical structures and ultrasonic coefficients after heating are obtained with a Fourier transform infrared spectroscopy and ultrasonic measurement, respectively. Optimized formula of the proposed hydrogel is 0.5% chitosan, 5% β-glycerophosphate, and 25% glycerol. This hydrogel has a high acoustic impedance (Z=1.8 Mrayl) close to that of human skin, high ultrasonic transmission (T=99%, which is normalized to water) from 25 to 55°C, and low attenuation coefficient (α=4.0Np/m). These properties assure the success of dual functions of the hydrogel developed in this work.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2016.04.028