Persistent pulmonary subsolid nodules with solid portions of 5 mm or smaller: Their natural course and predictors of interval growth

• Published in: European radiology 2016-06, Vol.26 (6), p.1529-1537
• Main Authors: Lee, Jong Hyuk, Park, Chang Min, Lee, Sang Min, Kim, Hyungjin, McAdams, H. Page, Goo, Jin Mo
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - diagnostic imaging; Adenocarcinoma - pathology; Adenocarcinoma in Situ - diagnostic imaging; Adenocarcinoma in Situ - pathology; Adult; Aged; Aged, 80 and over; Chest; Diagnostic Radiology; Disease Progression; Female; Humans; Hyperplasia; Imaging; Internal Medicine; Interventional Radiology; Kaplan-Meier Estimate; Lung cancer; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - pathology; Male; Medical research; Medical screening; Medicine; Medicine & Public Health; Middle Aged; Multiple Pulmonary Nodules - diagnostic imaging; Multiple Pulmonary Nodules - pathology; Neuroradiology; Patients; Proportional Hazards Models; Radiology; Retrospective Studies; Solitary Pulmonary Nodule - diagnostic imaging; Solitary Pulmonary Nodule - pathology; Surveillance; Tomography; Tomography, X-Ray Computed; Tumor Burden; Ultrasound; Young Adult
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-015-4017-4

Objective To investigate the natural course of persistent pulmonary subsolid nodules (SSNs) with solid portions ≤5 mm and the clinico-radiological features that influence interval growth over follow-ups. Methods From 2005 to 2013, the natural courses of 213 persistent SSNs in 213 patients were evaluated. To identify significant predictors of interval growth, Kaplan-Meier analysis and Cox proportional hazard regression analysis were performed. Results Among the 213 nodules, 136 were pure ground-glass nodules (GGNs; growth, 18; stable, 118) and 77 were part-solid GGNs with solid portions ≤5 mm (growth, 24; stable, 53). For all SSNs, lung cancer history ( p  = 0.001), part-solid GGNs ( p