Design, Synthesis, and Evaluation of Novel Auxin Mimic Herbicides

Due to the key roles of auxins as master regulators of plant growth, there is considerable interest in the development of compounds with auxin-like properties for growth management and weed control applications. Herein, we describe the design and multistep synthesis of ten compounds bearing combinat...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2016-05, Vol.64 (18), p.3533-3537
Main Authors: Do-Thanh, Chi-Linh, Vargas, Jose J, Thomas, Joseph W, Armel, Gregory R, Best, Michael D
Format: Article
Language:English
Subjects:
Drug Design
Drug Evaluation
Herbicides - chemical synthesis
Herbicides - chemistry
Herbicides - pharmacology
Indoleacetic Acids - chemical synthesis
Indoleacetic Acids - chemistry
Indoleacetic Acids - pharmacology
Plant Weeds - drug effects
Zea mays - drug effects
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Summary:Due to the key roles of auxins as master regulators of plant growth, there is considerable interest in the development of compounds with auxin-like properties for growth management and weed control applications. Herein, we describe the design and multistep synthesis of ten compounds bearing combinations of functional groups commonly associated with auxin-type properties. Following synthesis, these compounds were tested against multiple weed species as well as sweet corn. In general, while these structures were not quite as active as commercial auxin mimic herbicides, multiple compounds exhibited broadleaf weed activity with concurrent selectivity in sweet corn (Zea mays L. var. saccharum). In addition, differential results were observed upon subtle changes to structure, providing insights into the structural properties required for activity.
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.6b00675