Development of Point of Care Testing Device for Neurovascular Coupling From Simultaneous Recording of EEG and NIRS During Anodal Transcranial Direct Current Stimulation

This paper presents a point of care testing device for neurovascular coupling (NVC) from simultaneous recording of electroencephalogram (EEG) and near infrared spectroscopy (NIRS) during anodal transcranial direct current stimulation (tDCS). Here, anodal tDCS modulated cortical neural activity leadi...

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Bibliographic Details
Published in:IEEE journal of translational engineering in health and medicine 2015, Vol.3, p.1-12
Main Authors: Jindal, Utkarsh, Sood, Mehak, Dutta, Anirban, Chowdhury, Shubhajit Roy
Format: Article
Language:English
Subjects:
Diseases
Electroencephalogram
Electroencephalography
Engineering Sciences
Hemodynamics
Hilbert- Huang Transform
near infrared spectroscopy
Neurovascular coupling
Neurovascular Devices and Systems
Phantoms
Small vessel diseases
Stroke
transcranial direct current stimulation
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Summary:This paper presents a point of care testing device for neurovascular coupling (NVC) from simultaneous recording of electroencephalogram (EEG) and near infrared spectroscopy (NIRS) during anodal transcranial direct current stimulation (tDCS). Here, anodal tDCS modulated cortical neural activity leading to hemodynamic response can be used to identify the impaired cerebral microvessels functionality. The impairments in the cerebral microvessels functionality may lead to impairments in the cerebrovascular reactivity (CVR), where severely reduced CVR predicts the chances of transient ischemic attack and ipsilateral stroke. The neural and hemodynamic responses to anodal tDCS were studied through joint imaging with EEG and NIRS, where NIRS provided optical measurement of changes in tissue oxy-(HbO2) and deoxy-(Hb) hemoglobin concentration and EEG captured alterations in the underlying neuronal current generators. Then, a cross-correlation method for the assessment of NVC underlying the site of anodal tDCS is presented. The feasibility studies on healthy subjects and stroke survivors showed detectable changes in the EEG and the NIRS responses to a 0.526 A/m2 of anodal tDCS. The NIRS system was bench tested on 15 healthy subjects that showed a statistically significant (p
ISSN:2168-2372
2168-2372
DOI:10.1109/JTEHM.2015.2389230