Detection of specific immunoglobulin E antibodies toward common airborne allergens, peanut, wheat, and latex in solvent/detergent-treated pooled plasma

BACKGROUND Allergic transfusion reactions (ATRs) present with a broad range of symptoms probably caused by mediators released from mast cells and basophil granulocytes upon activation. Passive immunoglobulin (Ig)E sensitization may yield clinical symptoms and positive allergy tests. Unexpected findi...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2016-05, Vol.56 (5), p.1185-1191
Main Authors: Apelseth, Torunn O., Kvalheim, Venny L., Kristoffersen, Einar K.
Format: Article
Language:English
Subjects:
Allergens - immunology
Allergies
Animals
Antibodies - analysis
Arachis - immunology
Detergents - pharmacology
Humans
Immunoglobulin E - analysis
Immunoglobulin E - immunology
Immunoglobulins
Investigations
Latex - immunology
Plasma
Plasma - drug effects
Plasma - immunology
Prospective Studies
Solvents - pharmacology
Triticum - immunology
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Summary:BACKGROUND Allergic transfusion reactions (ATRs) present with a broad range of symptoms probably caused by mediators released from mast cells and basophil granulocytes upon activation. Passive immunoglobulin (Ig)E sensitization may yield clinical symptoms and positive allergy tests. Unexpected findings of IgE antibodies in pooled solvent/detergent (S/D)‐treated plasma (Octaplas, Octapharma) during routine analysis initiated an investigation of serum proteins. STUDY DESIGN AND METHODS Consecutive batches of S/D‐plasma transfused during September 2014 through March 2015 were investigated for IgE, IgG, IgA IgM, C3, C4, haptoglobin, anti‐nuclear antibodies (ANAs), and red blood cell (RBC) antibodies. RESULTS During the study period, 4203 S/D‐plasma units were transfused. Nineteen (14 Octaplas A and five Octaplas AB) of 20 batches of S/D‐plasma were included, representing 99.9% of total number of plasma units. A total of 0.4% of units and five batches reported ATRs. Concentrations of total IgE higher than expected values in adults (
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.13451