The prognostic value of non-perfusion variables obtained during vasodilator stress myocardial perfusion imaging

Myocardial perfusion imaging (MPI) is an established diagnostic test that provides useful prognostic data in patients with known or suspected coronary artery disease. In more than half of the patients referred for stress testing, vasodilator stress is used in lieu of exercise. Unlike exercise, vasod...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2016-06, Vol.23 (3), p.390-413
Main Authors: Bajaj, Navkaranbir S., Singh, Siddharth, Farag, Ayman, EL-Hajj, Stephanie, Heo, Jack, Iskandrian, Ami E., Hage, Fadi G.
Format: Article
Language:English
Subjects:
Cardiology
CME Article Review Article
Coronary Artery Disease - complications
Coronary Artery Disease - diagnostic imaging
Exercise Test - methods
Female
heart rate response
Humans
Imaging
Male
Medicine
Medicine & Public Health
Myocardial perfusion imaging
Myocardial Perfusion Imaging - methods
Nuclear Medicine
perfusion
Prognosis
Radiology
Reproducibility of Results
Risk Assessment - methods
Sensitivity and Specificity
SPECT
Tomography, Emission-Computed, Single-Photon - methods
transient ischemic dilation
vasodilator
Vasodilator Agents
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - etiology
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Summary:Myocardial perfusion imaging (MPI) is an established diagnostic test that provides useful prognostic data in patients with known or suspected coronary artery disease. In more than half of the patients referred for stress testing, vasodilator stress is used in lieu of exercise. Unlike exercise, vasodilator stress does not provide information on exercise and functional capacity, heart rate recovery, and chronotropy, and ECG changes are less frequent. These non-perfusion data provide important prognostic and patient management information. Further, event rates in patients undergoing vasodilator MPI are higher than in those undergoing exercise MPI and even in those with normal images probably due to higher pretest risk. However, there are a number of non-perfusion variables that are obtained during vasodilator stress testing, which have prognostic relevance but their use has not been well emphasized. The purpose of this review is to summarize the prognostic values of these non-perfusion data obtained during vasodilator MPI.
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-016-0441-3