Invasive micropapillary salivary duct carcinoma mixed with mucin-rich salivary duct carcinoma in minor salivary gland: a rare case report

Background Invasive micropapillary salivary duct carcinoma (SDC) is a rare variant of SDC. Although several cases involving major salivary glands have been reported, no cases arising de novo in minor salivary glands have been reported to date. Here we report the first case of invasive micropapillary...

Full description

Saved in:
Bibliographic Details
Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2016-06, Vol.121 (6), p.e162-e167
Main Authors: Tomihara, Kei, DDS, PhD, Miwa, Shigeharu, MD, PhD, Takazakura, Takeshi, DDS, Kamisaki, Yuichi, MD, PhD, Noguchi, Makoto, DDS, PhD
Format: Article
Language:English
Subjects:
Adenocarcinoma, Mucinous - pathology
Aged
Biomarkers, Tumor - analysis
Carcinoma, Papillary - pathology
Dentistry
Fatal Outcome
Humans
Lymphatic Metastasis
Male
Neoplasm Invasiveness - pathology
Salivary Gland Neoplasms - pathology
Salivary Glands, Minor - pathology
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Invasive micropapillary salivary duct carcinoma (SDC) is a rare variant of SDC. Although several cases involving major salivary glands have been reported, no cases arising de novo in minor salivary glands have been reported to date. Here we report the first case of invasive micropapillary SDC that arose in a minor salivary gland of the parapharyngeal space. Methods A 72-year-old male patient presented with an enlarging mass in the left parapharyngeal region along with trismus and swollen lymph nodes. Clinical examinations and biopsy findings were suggestive of a salivary gland malignant tumor with regional lymph node metastases. The tumor, therefore, was excised with partial mandibulectomy with unilateral radical neck dissection. Results Histologically, the tumor consisted of an invasive micropapillary growth pattern of SDC and mixed with mucinous component of SDC. Local recurrence and lung metastasis developed, and the patient died of disease 13 months after the initial treatment. Conclusions We describe the clinical and histologic features of this extremely rare case of minor salivary gland SDC that was histologically characterized by the presence of both invasive micropapillary growth pattern and mucinous component.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2015.10.012