CD1a+ dendritic cells in oral lichen planus and amalgam lichenoid reaction

Abstract Objective To evaluate and compare the number of CD1a+ dendritic cells (DCs) in oral lichen planus (OLP), amalgam lichenoid reaction (ALR) and normal oral mucosa (NOM). Study design Fourteen cases of OLP and ALR, diagnosed both clinically and histologically, were obtained from an archive of...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2016-06, Vol.121 (6), p.651-656
Main Authors: Souto, Giovanna Ribeiro, DDS, PhD, Nunes, Laiz Fernandes Mendes, DDS student, Tanure, Barbara Brandão, DDS, Gomez, Ricardo Santiago, DDS, PhD, Mesquita, Ricardo Alves, DDS, PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, CD1 - analysis
Cell Count
Dendritic Cells - pathology
Dental Amalgam - adverse effects
Dentistry
Female
Humans
Immunohistochemistry
Lichen Planus, Oral - pathology
Male
Middle Aged
Mouth Mucosa - pathology
Surgery
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Summary:Abstract Objective To evaluate and compare the number of CD1a+ dendritic cells (DCs) in oral lichen planus (OLP), amalgam lichenoid reaction (ALR) and normal oral mucosa (NOM). Study design Fourteen cases of OLP and ALR, diagnosed both clinically and histologically, were obtained from an archive of an oral pathology service. Seven specimens of NOM were collected and served as controls. Immunohistochemistry was used to identify CD1a+ DCs. Densities were calculated using specimens of epithelium and lamina propria. For OLP and ALR, specimens of lamina propria included cells from inflammatory infiltrate (region A), and from below inflammatory infiltrate (region B). Comparisons and statistical analyses were performed among OLP, ALR, and NOM. Results : A higher density of CD1a+ DCs was observed in OLP compared to ALR in region A (p
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2016.02.009