Prognostic significance of GRP78/BiP expression in patients with Stage III/IV hypopharyngeal squamous cell carcinoma

The immunoglobulin heavy chain binding protein (BiP)/glucose-regulated protein 78 (GRP78) plays an essential role in the endoplasmic reticulum (ER) stress, and GRP78/BiP is known to be highly expressed in various human neoplasms. The clinicopathological features of GRP78/BiP expression in patients w...

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Bibliographic Details
Published in:Neoplasma 2016, Vol.63 (3), p.477-483
Main Authors: Kaira, K, Toyoda, M, Shimizu, A, Imai, H, Sakakura, K, Nikkuni, O, Suzuki, M, Iijima, M, Asao, T, Chikamatsu, K
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Endoplasmic Reticulum Stress
Female
Heat-Shock Proteins - biosynthesis
Humans
Hypopharyngeal Neoplasms - blood supply
Hypopharyngeal Neoplasms - metabolism
Hypopharyngeal Neoplasms - pathology
Immunohistochemistry
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Staging
Prognosis
Progression-Free Survival
Squamous Cell Carcinoma of Head and Neck - blood supply
Squamous Cell Carcinoma of Head and Neck - metabolism
Squamous Cell Carcinoma of Head and Neck - pathology
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Summary:The immunoglobulin heavy chain binding protein (BiP)/glucose-regulated protein 78 (GRP78) plays an essential role in the endoplasmic reticulum (ER) stress, and GRP78/BiP is known to be highly expressed in various human neoplasms. The clinicopathological features of GRP78/BiP expression in patients with advanced hypopharyngeal squamous cell carcinoma (HSCC) remain unclear. The aim of this study is to elucidate the prognostic significance of GRP78/BiP for HSCC.A total of 68 patients with advanced HSCC (stage III/IV) were analyzed, and tumor specimens were stained with immunohistochemistry for GRP78/BiP, Ki-67, and microvessel density (MVD), as determined through CD34 and p53 levels. GRP78/BiP was highly expressed in 80.8% (55/68) of all patients. The expression level of GRP78/BiP disclosed no significant relationship with any variables. Multivariate analysis confirmed that low expression of GRP78/BiP was an independent prognostic factor for predicting poor overall survival and progression-free survival in patients with advanced HSCC. The decreasing expression of GRP78/BiP was identified as a significant predictor related to shorter survival duration after surgery for advanced HSCC. Our study suggests that the reduced expression of GRP78/BiP contributes to worse survival for patients with advanced head and neck cancer.
ISSN:0028-2685
DOI:10.4149/319_151002N513