Characterizing and modeling concentration-response curves of olfactory receptor cells

The spike frequency of olfactory receptor cells in response to different odorants at various concentrations was measured experimentally. The concentration-response curves were constructed and characterized by biologically significant parameters measuring the amplitude, sensitivity and dynamic range...

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Bibliographic Details
Published in:Neurocomputing (Amsterdam) 2001-06, Vol.38, p.319-325
Main Authors: Rospars, Jean-Pierre, Lánský, Petr, Duchamp-Viret, Patricia, Duchamp, André
Format: Article
Language:English
Subjects:
Frequency coding
Interspike interval
Olfaction
Receptor neuron
Transduction
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Summary:The spike frequency of olfactory receptor cells in response to different odorants at various concentrations was measured experimentally. The concentration-response curves were constructed and characterized by biologically significant parameters measuring the amplitude, sensitivity and dynamic range of the responses. The parameters that vary independently for different odorants and neurons are candidates for qualitative coding in olfaction. The curves can be accounted for by a model of the receptor cell we developed. This model suggests that most of the variability in sensitivity results from the variability of odorant–receptor binding characteristics.
ISSN:0925-2312
1872-8286
DOI:10.1016/S0925-2312(01)00354-X