Lysosomal phospholipase A sub(1) in Trypanosoma cruzi: an enzyme with a possible role in the pathogenesis of Chagas' disease

We found that, as in African trypanosomes, endogenous phospholipase A sub(1) (Plase A sub(1)) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A sub(1) was purified and characterized. The enzyme products can...

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Bibliographic Details
Published in:Biochemical journal 2001-05, Vol.355 (3), p.765-770
Main Authors: Wainszelbaum, M, Isola, E, Wilkowsky, S, Cannata, JJB, Florin-Christensen, J, Florin-Christensen, M
Format: Article
Language:English
Subjects:
phospholipase A1
Trypanosoma cruzi
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Summary:We found that, as in African trypanosomes, endogenous phospholipase A sub(1) (Plase A sub(1)) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A sub(1) was purified and characterized. The enzyme products can explain the lesions surrounding degenerating T. cruzi cells in host tissues. Thus Plase A sub(1) emerges as a target to block pathogenesis in trypanosomal infections.
ISSN:0264-6021