Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating n...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2016-05, Vol.8 (19), p.12039-12047
Main Authors: Hu, Wenbo, Ma, Hengheng, Hou, Bing, Zhao, Hui, Ji, Yu, Jiang, Rongcui, Hu, Xiaoming, Lu, Xiaomei, Zhang, Lei, Tang, Yufu, Fan, Quli, Huang, Wei
Format: Article
Language:English
Subjects:
3T3 Cells
A549 Cells
Animals
Boron Compounds - chemistry
Boron Compounds - pharmacology
Drug Delivery Systems
Humans
Lysosomes - metabolism
Mice
Mice, Nude
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Neoplasms - diagnostic imaging
Neoplasms - drug therapy
Photoacoustic Techniques
Photochemotherapy
Xenograft Model Antitumor Assays
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Summary:Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.6b02721