Effect of the Cymbopogon citratus, Maytenus ilicifolia and Baccharis genistelloides extracts against the stannous chloride oxidative damage in Escherichia coli

Stannous ion has been used in different sectors of human interest, such as in food industry and in health sciences. Much is known about stannous chloride (SnCl 2) toxicity, although, there is no general agreement regarding its genotoxicity. Cymbopogon citratus, Maytenus ilicifolia and Baccharis geni...

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Published in:Mutation research. Genetic toxicology and environmental mutagenesis 2001-09, Vol.496 (1), p.33-38
Main Authors: de F. Melo, Suzana, Soares, Scheila F, da Costa, Rogério F, da Silva, Claudia R, de Oliveira, Marcia B.N, Bezerra, Roberto J.A.C, Caldeira-de-Araújo, Adriano, Bernardo-Filho, Mario
Format: Article
Language:English
Subjects:
Baccharis genistelloides
Cymbopogon citratus
Escherichia coli
Maytenus ilicifolia
Reactive oxygen species
Redox action
stannous chloride
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Summary:Stannous ion has been used in different sectors of human interest, such as in food industry and in health sciences. Much is known about stannous chloride (SnCl 2) toxicity, although, there is no general agreement regarding its genotoxicity. Cymbopogon citratus, Maytenus ilicifolia and Baccharis genistelloides extracts have been used in popular medicine. We evaluated the influence of these crude extracts on the survival of the Escherichia coli wild type (AB 1157) strain submitted to SnCl 2 treatment. Reactive oxygen species (ROS) can be generated by a Fenton like reaction induced by SnCl 2. E. coli culture was treated simultaneously with SnCl 2 and a specific extract. Our results showed a reduction of the SnCl 2 effect on the survival of the cultures in presence of the crude extracts. The extract of M. ilicifolia showed the highest level of protection action against the SnCl 2 effect in comparison with the other extracts. This protector effect could due to the redox properties of these crude extracts. The compounds in the crude extracts could (i) chelate stannous ions, protecting them against the oxidation and avoiding the generation of ROS, (ii) be a scavenger of the ROS generated by the SnCl 2 oxidation and/or (iii) have oxidant compounds that could oxidise the stannous ions, abolishing or reducing the SnCl 2 effect.
ISSN:1383-5718
1879-3592
DOI:10.1016/S1383-5718(01)00216-9