Bone as a biomarker of acute fluoride toxicity

The use of bone as a biomarker for chronic and acute exposure to fluoride salts has been suggested, but there are no data published about its use to evaluate lethal intoxication. One hundred and sixty rats were divided into eight groups that received a single oral intubation dose from 0 (control) to...

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Bibliographic Details
Published in:Forensic science international 2003-11, Vol.137 (2), p.209-214
Main Authors: Bezerra de Menezes, Léa Maria, Volpato, Maria Cristina, Rosalen, Pedro Luiz, Cury, Jaime Aparecido
Format: Article
Language:English
Subjects:
Acute toxicity
Animals
Biological and medical sciences
Biomarker
Biomarkers
Bone
Bone density
Cariostatic Agents - administration & dosage
Cariostatic Agents - analysis
Cariostatic Agents - toxicity
Dental care
Dental caries
Female
Femur - chemistry
Fluoridation
Fluoride
Fluorides
Fluorides - administration & dosage
Fluorides - analysis
Fluorides - toxicity
Forensic sciences
Fundamental and applied biological sciences. Psychology
Male
Rats
Rats, Wistar
Skeleton and joints
Studies
Toxicity
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:The use of bone as a biomarker for chronic and acute exposure to fluoride salts has been suggested, but there are no data published about its use to evaluate lethal intoxication. One hundred and sixty rats were divided into eight groups that received a single oral intubation dose from 0 (control) to 90 mg F/kg as NaF. The animals’ time of death was recorded and their femurs were removed for fluoride analysis. Acid-soluble fluoride was determined in the whole bone and on the surface (periosteal), using an ion specific electrode. The data showed a statistically significant relationship between fluoride dose and the number of deaths ( P
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2003.08.001