Antitumor effect of arabinogalactan and platinum complex

• Published in: Doklady. Biochemistry and biophysics 2016-03, Vol.467 (1), p.92-94
• Main Authors: Starkov, A. K., Zamay, T. N., Savchenko, A. A., Ingevatkin, E. V., Titova, N. M., Kolovskaya, O. S., Luzan, N. A., Silkin, P. P., Kuznetsova, S. A.
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - pharmacology; Ascites - drug therapy; Ascites - metabolism; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Biophysics and Molecular Biology; Carcinoma, Ehrlich Tumor - drug therapy; Carcinoma, Ehrlich Tumor - metabolism; Cell growth; Cisplatin - pharmacology; Drug Evaluation, Preclinical; Erythrocytes - drug effects; Erythrocytes - metabolism; Galactans - chemical synthesis; Galactans - pharmacokinetics; Galactans - pharmacology; Kidney - drug effects; Kidney - metabolism; Life Sciences; Liver - drug effects; Liver - metabolism; Lymphocytes - drug effects; Lymphocytes - metabolism; Male; Mice, Inbred ICR; Microscopy, Fluorescence; Neoplasm Transplantation; Organoplatinum Compounds - chemical synthesis; Organoplatinum Compounds - pharmacokinetics; Organoplatinum Compounds - pharmacology; Platinum; Tissues; Tumors
• ISSN: 1607-6729; 1608-3091
• DOI: 10.1134/S1607672916020046

The article presents the results of investigation of antitumor properties of platinum–arabinogalactan complex. We showed the ability of the complex to inhibit the growth of Ehrlich ascites tumor cells. It is found that the distribution of the platinum–arabinogalactan complex is not specific only for tumor cells in mice. The complex was found in all tissues and organs examined (ascites cells, embryonic cells, kidney, and liver). The mechanism of action of the arabinogalactan–platinum complex may be similar to cisplatin as the complex is able to accumulate in tumor cells.