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Antitumor effect of arabinogalactan and platinum complex
The article presents the results of investigation of antitumor properties of platinum–arabinogalactan complex. We showed the ability of the complex to inhibit the growth of Ehrlich ascites tumor cells. It is found that the distribution of the platinum–arabinogalactan complex is not specific only for...
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| Published in: | Doklady. Biochemistry and biophysics 2016-03, Vol.467 (1), p.92-94 |
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| Main Authors: | , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c372t-69e037ab8dabe30476e8f7ce1e3fa9bbf0d2ab6d932e742262f952ec4b39e75c3 |
| container_end_page | 94 |
| container_issue | 1 |
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| container_title | Doklady. Biochemistry and biophysics |
| container_volume | 467 |
| creator | Starkov, A. K. Zamay, T. N. Savchenko, A. A. Ingevatkin, E. V. Titova, N. M. Kolovskaya, O. S. Luzan, N. A. Silkin, P. P. Kuznetsova, S. A. |
| description | The article presents the results of investigation of antitumor properties of platinum–arabinogalactan complex. We showed the ability of the complex to inhibit the growth of Ehrlich ascites tumor cells. It is found that the distribution of the platinum–arabinogalactan complex is not specific only for tumor cells in mice. The complex was found in all tissues and organs examined (ascites cells, embryonic cells, kidney, and liver). The mechanism of action of the arabinogalactan–platinum complex may be similar to cisplatin as the complex is able to accumulate in tumor cells. |
| doi_str_mv | 10.1134/S1607672916020046 |
| format | article |
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K. ; Zamay, T. N. ; Savchenko, A. A. ; Ingevatkin, E. V. ; Titova, N. M. ; Kolovskaya, O. S. ; Luzan, N. A. ; Silkin, P. P. ; Kuznetsova, S. A.</creator><creatorcontrib>Starkov, A. K. ; Zamay, T. N. ; Savchenko, A. A. ; Ingevatkin, E. V. ; Titova, N. M. ; Kolovskaya, O. S. ; Luzan, N. A. ; Silkin, P. P. ; Kuznetsova, S. A.</creatorcontrib><description>The article presents the results of investigation of antitumor properties of platinum–arabinogalactan complex. We showed the ability of the complex to inhibit the growth of Ehrlich ascites tumor cells. It is found that the distribution of the platinum–arabinogalactan complex is not specific only for tumor cells in mice. The complex was found in all tissues and organs examined (ascites cells, embryonic cells, kidney, and liver). The mechanism of action of the arabinogalactan–platinum complex may be similar to cisplatin as the complex is able to accumulate in tumor cells.</description><identifier>ISSN: 1607-6729</identifier><identifier>EISSN: 1608-3091</identifier><identifier>DOI: 10.1134/S1607672916020046</identifier><identifier>PMID: 27193706</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Animals ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - pharmacokinetics ; Antineoplastic Agents - pharmacology ; Ascites - drug therapy ; Ascites - metabolism ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Biophysics and Molecular Biology ; Carcinoma, Ehrlich Tumor - drug therapy ; Carcinoma, Ehrlich Tumor - metabolism ; Cell growth ; Cisplatin - pharmacology ; Drug Evaluation, Preclinical ; Erythrocytes - drug effects ; Erythrocytes - metabolism ; Galactans - chemical synthesis ; Galactans - pharmacokinetics ; Galactans - pharmacology ; Kidney - drug effects ; Kidney - metabolism ; Life Sciences ; Liver - drug effects ; Liver - metabolism ; Lymphocytes - drug effects ; Lymphocytes - metabolism ; Male ; Mice, Inbred ICR ; Microscopy, Fluorescence ; Neoplasm Transplantation ; Organoplatinum Compounds - chemical synthesis ; Organoplatinum Compounds - pharmacokinetics ; Organoplatinum Compounds - pharmacology ; Platinum ; Tissues ; Tumors</subject><ispartof>Doklady. 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The mechanism of action of the arabinogalactan–platinum complex may be similar to cisplatin as the complex is able to accumulate in tumor cells.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Ascites - drug therapy</subject><subject>Ascites - metabolism</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Biophysics and Molecular Biology</subject><subject>Carcinoma, Ehrlich Tumor - drug therapy</subject><subject>Carcinoma, Ehrlich Tumor - metabolism</subject><subject>Cell growth</subject><subject>Cisplatin - pharmacology</subject><subject>Drug Evaluation, Preclinical</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - metabolism</subject><subject>Galactans - chemical synthesis</subject><subject>Galactans - pharmacokinetics</subject><subject>Galactans - pharmacology</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Life Sciences</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Mice, Inbred ICR</subject><subject>Microscopy, Fluorescence</subject><subject>Neoplasm Transplantation</subject><subject>Organoplatinum Compounds - chemical synthesis</subject><subject>Organoplatinum Compounds - pharmacokinetics</subject><subject>Organoplatinum Compounds - pharmacology</subject><subject>Platinum</subject><subject>Tissues</subject><subject>Tumors</subject><issn>1607-6729</issn><issn>1608-3091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLxDAUhYMozjj6A9xIwY2bal5NmuUw-ALBhbouSXozdGibMWlB_70ZZxRRXJ0L57vnXg5CpwRfEsL41RMRWApJVVKKMRd7aJrGMmdYkf3PWeYbf4KOYlzhBFFWHKIJlUQxicUUlfN-aIax8yED58AOmXeZDto0vV_qVttB95nu62zd6qHpxy6zvlu38HaMDpxuI5zsdIZebq6fF3f5w-Pt_WL-kFsm6ZALBZhJbcpaG2CYSwGlkxYIMKeVMQ7XVBtRK0ZBckoFdaqgYLlhCmRh2QxdbHPXwb-OEIeqa6KFttU9-DFWRCrMC0oJT-j5L3Tlx9Cn7xJVKsVVIViiyJaywccYwFXr0HQ6vFcEV5taqz-1pp2zXfJoOqi_N756TADdAjFZ_RLCj9P_pn4AhQmAfw</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Starkov, A. 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K. ; Zamay, T. N. ; Savchenko, A. A. ; Ingevatkin, E. V. ; Titova, N. M. ; Kolovskaya, O. S. ; Luzan, N. A. ; Silkin, P. P. ; Kuznetsova, S. 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Biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Starkov, A. K.</au><au>Zamay, T. N.</au><au>Savchenko, A. A.</au><au>Ingevatkin, E. V.</au><au>Titova, N. M.</au><au>Kolovskaya, O. S.</au><au>Luzan, N. A.</au><au>Silkin, P. P.</au><au>Kuznetsova, S. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antitumor effect of arabinogalactan and platinum complex</atitle><jtitle>Doklady. Biochemistry and biophysics</jtitle><stitle>Dokl Biochem Biophys</stitle><addtitle>Dokl Biochem Biophys</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>467</volume><issue>1</issue><spage>92</spage><epage>94</epage><pages>92-94</pages><issn>1607-6729</issn><eissn>1608-3091</eissn><abstract>The article presents the results of investigation of antitumor properties of platinum–arabinogalactan complex. We showed the ability of the complex to inhibit the growth of Ehrlich ascites tumor cells. It is found that the distribution of the platinum–arabinogalactan complex is not specific only for tumor cells in mice. The complex was found in all tissues and organs examined (ascites cells, embryonic cells, kidney, and liver). The mechanism of action of the arabinogalactan–platinum complex may be similar to cisplatin as the complex is able to accumulate in tumor cells.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>27193706</pmid><doi>10.1134/S1607672916020046</doi><tpages>3</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Ascites - drug therapy Ascites - metabolism Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biophysics and Molecular Biology Carcinoma, Ehrlich Tumor - drug therapy Carcinoma, Ehrlich Tumor - metabolism Cell growth Cisplatin - pharmacology Drug Evaluation, Preclinical Erythrocytes - drug effects Erythrocytes - metabolism Galactans - chemical synthesis Galactans - pharmacokinetics Galactans - pharmacology Kidney - drug effects Kidney - metabolism Life Sciences Liver - drug effects Liver - metabolism Lymphocytes - drug effects Lymphocytes - metabolism Male Mice, Inbred ICR Microscopy, Fluorescence Neoplasm Transplantation Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - pharmacokinetics Organoplatinum Compounds - pharmacology Platinum Tissues Tumors |
| title | Antitumor effect of arabinogalactan and platinum complex |
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