Effects of profound hypothermia on the blood–brain barrier permeability in acute and chronically ethanol treated rats

This study examines the effects of profound hypothermia on the blood–brain barrier (BBB) permeability in ethanol administrated rats. Vascular permeability to intravenously injected Evans blue (EB) was quantitatively examined in the brain regions of rats. Rats were treated with ethanol acute and chro...

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Bibliographic Details
Published in:Forensic science international 2001-06, Vol.119 (2), p.212-216
Main Authors: Elmas, Imdat, Küçük, Mutlu, Kalayci, Rivaze Bulut, Çevik, Aydin, Kaya, Mehmet
Format: Article
Language:English
Subjects:
Acute Disease
Alcoholism
Alcoholism - complications
Animals
Biological and medical sciences
Blood pressure
Blood-Brain Barrier
Body Temperature
Brain research
Chronic Disease
Cold
Disease Models, Animal
Drinking water
Dyes
Ethanol
Evans blue
Evans Blue - pharmacokinetics
Forensic Medicine
Forensic sciences
Hypothermia
Hypothermia - complications
Hypothermia - metabolism
Injections, Intravenous
Male
Medical sciences
Membrane permeability
Permeability
Public health. Hygiene
Public health. Hygiene-occupational medicine
Rats
Rats, Wistar
Rectum
Statistical significance
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Summary:This study examines the effects of profound hypothermia on the blood–brain barrier (BBB) permeability in ethanol administrated rats. Vascular permeability to intravenously injected Evans blue (EB) was quantitatively examined in the brain regions of rats. Rats were treated with ethanol acute and chronically. Rectal temperature of rats was dropped into 20±1°C during profound hypothermia. Mean arterial blood pressure in both acute and chronic ethanol treatments plus hypothermia significantly dropped into low levels as well as in hypothermia alone ( P
ISSN:0379-0738
1872-6283
DOI:10.1016/S0379-0738(00)00429-1