Effects of profound hypothermia on the blood–brain barrier permeability in acute and chronically ethanol treated rats

This study examines the effects of profound hypothermia on the blood–brain barrier (BBB) permeability in ethanol administrated rats. Vascular permeability to intravenously injected Evans blue (EB) was quantitatively examined in the brain regions of rats. Rats were treated with ethanol acute and chro...

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Published in:Forensic science international 2001-06, Vol.119 (2), p.212-216
Main Authors: Elmas, Imdat, Küçük, Mutlu, Kalayci, Rivaze Bulut, Çevik, Aydin, Kaya, Mehmet
Format: Article
Language:English
Subjects:
Acute Disease
Alcoholism
Alcoholism - complications
Animals
Biological and medical sciences
Blood pressure
Blood-Brain Barrier
Body Temperature
Brain research
Chronic Disease
Cold
Disease Models, Animal
Drinking water
Dyes
Ethanol
Evans blue
Evans Blue - pharmacokinetics
Forensic Medicine
Forensic sciences
Hypothermia
Hypothermia - complications
Hypothermia - metabolism
Injections, Intravenous
Male
Medical sciences
Membrane permeability
Permeability
Public health. Hygiene
Public health. Hygiene-occupational medicine
Rats
Rats, Wistar
Rectum
Statistical significance
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creator Elmas, Imdat
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description This study examines the effects of profound hypothermia on the blood–brain barrier (BBB) permeability in ethanol administrated rats. Vascular permeability to intravenously injected Evans blue (EB) was quantitatively examined in the brain regions of rats. Rats were treated with ethanol acute and chronically. Rectal temperature of rats was dropped into 20±1°C during profound hypothermia. Mean arterial blood pressure in both acute and chronic ethanol treatments plus hypothermia significantly dropped into low levels as well as in hypothermia alone ( P
doi_str_mv 10.1016/S0379-0738(00)00429-1
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Vascular permeability to intravenously injected Evans blue (EB) was quantitatively examined in the brain regions of rats. Rats were treated with ethanol acute and chronically. Rectal temperature of rats was dropped into 20±1°C during profound hypothermia. Mean arterial blood pressure in both acute and chronic ethanol treatments plus hypothermia significantly dropped into low levels as well as in hypothermia alone ( P&lt;0.01). Hypothermia led to a significant increase in the content of EB dye in the brain regions of rats ( P&lt;0.05). Both acute and chronic ethanol treatments plus hypothermia did not lead to a significant increase in the BBB permeability against intravenously injected EB dye. 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identifier ISSN: 0379-0738
ispartof Forensic science international, 2001-06, Vol.119 (2), p.212-216
issn 0379-0738
1872-6283
language eng
recordid cdi_proquest_miscellaneous_17904528
source Elsevier
subjects Acute Disease
Alcoholism
Alcoholism - complications
Animals
Biological and medical sciences
Blood pressure
Blood-Brain Barrier
Body Temperature
Brain research
Chronic Disease
Cold
Disease Models, Animal
Drinking water
Dyes
Ethanol
Evans blue
Evans Blue - pharmacokinetics
Forensic Medicine
Forensic sciences
Hypothermia
Hypothermia - complications
Hypothermia - metabolism
Injections, Intravenous
Male
Medical sciences
Membrane permeability
Permeability
Public health. Hygiene
Public health. Hygiene-occupational medicine
Rats
Rats, Wistar
Rectum
Statistical significance
title Effects of profound hypothermia on the blood–brain barrier permeability in acute and chronically ethanol treated rats
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