Comparison of prostate cancer detection at 3-T MRI with and without an endorectal coil: A prospective, paired-patient study

Abstract Objectives To compare the sensitivity of 2 different non–endorectal coil strategies vs. endorectal coil (ERC) magnetic resonance imaging (MRI) for detection of prostate cancer (PCa). Methods In this prospective, single-center, paired-patient, paired-reader study, 49 men with a clinical indi...

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Published in:Urologic oncology 2016-06, Vol.34 (6), p.255.e7-255.e13
Main Authors: Costa, Daniel N., M.D, Yuan, Qing, Ph.D, Xi, Yin, Ph.D, Rofsky, Neil M., M.D, Lenkinski, Robert E., Ph.D, Lotan, Yair, M.D, Roehrborn, Claus G., M.D, Francis, Franto, M.D, Travalini, Debbie, PA-C, Pedrosa, Ivan, M.D
Format: Article
Language:English
Subjects:
Aged
Detection
Endorectal coil
Humans
Imaging
Magnetic Resonance Imaging
Male
Middle Aged
MRI
Prospective Studies
Prostate cancer
Prostatectomy
Prostatic Neoplasms - diagnostic imaging
Sensitivity and Specificity
Urology
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Summary:Abstract Objectives To compare the sensitivity of 2 different non–endorectal coil strategies vs. endorectal coil (ERC) magnetic resonance imaging (MRI) for detection of prostate cancer (PCa). Methods In this prospective, single-center, paired-patient, paired-reader study, 49 men with a clinical indication for MRI underwent non-ERC (phased-array coil only) T2-weighted imaging and diffusion-weighted imaging followed by the same sequences using both ERC and phased-array coils (ERC Protocol). Patients were randomized into 1 of 2 arms: standard non-ERC protocol and augmented non-ERC protocol. Lesions with Likert score≥3 were defined as suspicious for cancer. Radical prostatectomy specimen or combined systematic plus targeted biopsies served as the standard of reference. Cancers were stratified into risk groups according to the National Comprehensive Cancer Network guidelines. Generalized estimating equations with Bonferroni correction were used for comparisons. The level of reader confidence was inferred by the Likert scores assigned to index lesions. Results The ERC protocol provided sensitivity (78%) superior to MRI without ERC for PCa detection, both with a standard (43%) ( P
ISSN:1078-1439
1873-2496
DOI:10.1016/j.urolonc.2016.02.009