Detection of Gold Nanoparticles in Rat Organs by Transmission Electron Microscopy

The effects of water-dispersed gold nanoparticles (8.0±0.9 nm in diameter) on the rat small intestinal mucosa and Peyer plaques, liver, and spleen were studied by electron microscopy. Water-dispersed gold nanoparticles injected into isolated intestinal loop not only accumulated in the small intestin...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-04, Vol.160 (6), p.817-822
Main Authors: Platonova, T. A., Pridvorova, S. M., Zherdev, A. V., Gmoshinskii, I. V., Vasilevskaya, L. S., Dzantiev, B. B.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Biotechnologies
Cell Biology
Chemical properties
Electron microscopy
Endoplasmic Reticulum - drug effects
Endoplasmic Reticulum - pathology
Gold - pharmacokinetics
Gold - toxicity
Internal Medicine
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Intestinal Mucosa - pathology
Intestine, Small - drug effects
Intestine, Small - metabolism
Intestine, Small - pathology
Laboratory Medicine
Liver
Liver - drug effects
Liver - metabolism
Liver - pathology
Male
Metal Nanoparticles - toxicity
Microscopy, Electron, Transmission
Nanoparticles
Pathology
Rats, Wistar
Spleen - drug effects
Spleen - metabolism
Spleen - pathology
Tissue Distribution
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Description
Summary:The effects of water-dispersed gold nanoparticles (8.0±0.9 nm in diameter) on the rat small intestinal mucosa and Peyer plaques, liver, and spleen were studied by electron microscopy. Water-dispersed gold nanoparticles injected into isolated intestinal loop not only accumulated in the small intestinal mucosa and Peyer plaques, but also penetrated into other organs, e.g . liver and spleen. Ultrastructural changes in the cells (hyperplasia of endoplasmic reticulum) were detected in the studied organs.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3318-1