Novel round cells in urine sediment and their clinical implications

Voided urine contains a variety of cells from the kidney and urinary tract and urinalysis provides us various information by investigating cellular components. We investigated urine sediment from renal impaired patients. We found ‘round cell’ to be distinct from known cells in sediment and is close...

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Bibliographic Details
Published in:Clinica chimica acta 2016-06, Vol.457, p.142-149
Main Authors: Shukuya, Kenichi, Ogura, Sayoko, Tokuhara, Yasunori, Okubo, Shigeo, Yatomi, Yutaka, Tozuka, Minoru, Shimosawa, Tatsuo
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
PAX2
Renal tubular epithelial cell
Round cells
Urinalysis
Urine - cytology
Urine sediment
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Summary:Voided urine contains a variety of cells from the kidney and urinary tract and urinalysis provides us various information by investigating cellular components. We investigated urine sediment from renal impaired patients. We found ‘round cell’ to be distinct from known cells in sediment and is close to proximal convoluted tubule-derived cells based on morphology and molecular marker expression (GGT1 but not podocalyxin). Also it was positive for undifferentiated cell markers, including PAX2, WT1, OSR1, and SIX2. They were observed in end-stage renal failure patients and the number of cells was correlated with the severity of chronic kidney disease. A prospective analysis revealed that patients who had more round cells were more likely to require hemodialysis within a year. Round cells are a novel marker that can be used to predict the need for hemodialysis. •Novel round cells in urine sediments which is found either in and outside of cast•Round cell is positive for epithelial cell marker as well as undifferentiated cells.•The number of round cells possibly predicts renal death.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2016.04.017