Human Immunodeficiency Virus (HIV) Type 1 Antibodies in Perinatal HIV-1 Infection: Association with Human HIV-1 Transmission, Infection, and Disease Progression

Anti -human immunodeficiency virus (HIV) type 1 antibodies in 242 pregnant women and 238 infants were measured at birth and at 1, 2, 4, and 6 months after birth, to estimate their association with perinatal transmission and infant disease progression. Maternal anti—p24 (P = .01) and anti—gp120 (P =...

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Bibliographic Details
Published in:The Journal of infectious diseases 2000-10, Vol.182 (4), p.1243-1246
Main Authors: Pitt, Jane, Henrard, Denis, FitzGerald, Gordon, Mofenson, Lynne, Lew, Judy, Hillyer, George, Mendez, Hermann, Cooper, Ellen, Hanson, Celine, Rich, Kenneth C.
Format: Article
Language:English
Subjects:
Antibodies
Ap24 protein
Ap31 protein
Biological and medical sciences
Concise Communication
Disease progression
Disease transmission
Glycoprotein gp41
HIV
HIV 1
Human immunodeficiency virus 1
Human viral diseases
Infants
Infections
Infectious diseases
Medical sciences
Pediatrics
RNA
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viruses
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Summary:Anti -human immunodeficiency virus (HIV) type 1 antibodies in 242 pregnant women and 238 infants were measured at birth and at 1, 2, 4, and 6 months after birth, to estimate their association with perinatal transmission and infant disease progression. Maternal anti—p24 (P = .01) and anti—gp120 (P = .04) antibodies were inversely associated with vertical transmission rates, independent of maternal percentage of CD4 cells, hard drug use, duration of ruptured membranes, serum albumin levels, serum vitamin A levels, and quantitative HIV-1 peripheral mononuclear blood cell culture, but not with maternal plasma immune complex dissociated p24 or HIV-1 RNA copy number, both of which were highly correlated with antibodies. From ages 1–2 months, anti-gp120, -gp41, -p31, and -p66 decayed to a greater extent in infected than in uninfected infants. Infected infants produced anti-p24 antibody by age 2 months, anti-p17 by 4 months, and anti-p41 and anti-gp120 by 6 months. As early as birth, infants with rapid disease progression had lower levels of anti-p24 than did infants whose disease did not rapidly progress, but not independently of HIV-1 RNA levels.
ISSN:0022-1899
1537-6613
DOI:10.1086/315809