Effects of IL10-592 locus of AA genotype on the incidence of aGVHD and survival after HLA-matched unrelated allogeneic hematopoietic stem cell transplantation

• Published in: Zhōnghuá xuèyèxué zázhì 2016-05, Vol.37 (5), p.372-376
• Main Authors: Yang, Z L, Qiu, Q C, Ding, Z X, Pan, Z J, Zhao, Q Q, He, J
• Format: Article
• Language: Chinese
• Subjects: Disease-Free Survival; Genotype; Graft vs Host Disease - diagnosis; Graft vs Host Disease - genetics; Hematopoietic Stem Cell Transplantation; Humans; Incidence; Interleukin-10 - genetics; Polymorphism, Genetic; Prognosis; Transplantation, Homologous
• ISSN: 0253-2727
• DOI: 10.3760/cma.j.issn.0253-2727.2016.05.004

To explore the impact of IL10-592 (rs1800872) single nucleic acid polymorphism (SNP) on the prognosis of HLA matched unrelated hematopoietic stem cell transplantation (HSCT). The polymorphism of IL10-592 in 104 recipient-donor pairs and 100 healthy volunteers was analyzed with sequence based typing (SBT). When the genotype of IL10-592 in donors and recipients matched, AA/AA genotype had higher incidence of Ⅲ-Ⅳ aGVHD than AC/AC or CC/CC genotype (47.1%, 3.7%, 0, P=0.002). When the genotype of IL10-592 in donors and recipients mismatched, recipients with AC genotype or donors with AA genotype, there was significant different incidence of Ⅲ-ⅣaGVHD among donors or recipients with different genotype (P=0.046, P=0.041). The recipients with AA genotype had higher incidence of Ⅲ-Ⅳ aGVHD than AC or CC genotype (27.8% vs 10.2%, 11.1%; P=0.072), and higher incidence of intestinal aGVHD (22.2% vs 5.1%,11.1%; P=0.040) , lower incidence of 2-year overall survival (OS: 48.2% vs 75.1%, 85.7%; P=0.002), lower incidence of 2 y