The Role of Tumor-Infiltrating Lymphocytes in Development, Progression, and Prognosis of Non–Small Cell Lung Cancer

A malignant tumor is not merely an accumulation of neoplastic cells, but constitutes a microenvironment containing endothelial cells, fibroblasts, structural components, and infiltrating immune cells that impact tumor development, invasion, metastasis, and outcome. Hence, the evolution of cancers re...

Full description

Saved in:
Bibliographic Details
Published in:Journal of thoracic oncology 2016-06, Vol.11 (6), p.789-800
Main Authors: Bremnes, Roy M., Busund, Lill-Tove, Kilvær, Thomas L., Andersen, Sigve, Richardsen, Elin, Paulsen, Erna Elise, Hald, Sigurd, Khanehkenari, Mehrdad Rakaee, Cooper, Wendy A., Kao, Steven C., Dønnem, Tom
Format: Article
Language:English
Subjects:
Carcinoma, Non-Small-Cell Lung - immunology
Carcinoma, Non-Small-Cell Lung - pathology
Disease Progression
Humans
Immune context
Immunoscore
Lung Neoplasms - immunology
Lung Neoplasms - pathology
Lymphocytes, Tumor-Infiltrating - immunology
NSCLC
Prognosis
TILs
Tumor microenvironment
Tumor Microenvironment - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A malignant tumor is not merely an accumulation of neoplastic cells, but constitutes a microenvironment containing endothelial cells, fibroblasts, structural components, and infiltrating immune cells that impact tumor development, invasion, metastasis, and outcome. Hence, the evolution of cancers reflects intricate cellular and molecular interactions between tumor cells and constituents of the tumor microenvironment. Recent studies have shed new light on this complex interaction between tumor and host immune cells and the resulting immune response. The composition of the immune microenvironment differs across patients as well as in cancers of the same type, including various populations of T cells, B cells, dendritic cells, natural killer cells, myeloid-derived suppressor cells, neutrophils, and macrophages. The type, density, location, and organization of immune cells within solid tumors define the immune contexture, which has proved to be a major determinant of tumor characteristics and patient outcome. Lung cancer consists mostly of non–small cell lung cancer (85%); it is our most deadly malignant disease, with the 5-year survival rate being merely 15%. This review focuses on the immune contexture; the tumor-suppressing roles of tumor-infiltrating lymphocytes; and the relevance of this immune contexture for cancer diagnostics, prognostication, and treatment allocation, with an emphasis on non–small cell lung cancer.
ISSN:1556-0864
1556-1380
DOI:10.1016/j.jtho.2016.01.015