Exploring the use of nanocarrier systems to deliver the magical molecule; Curcumin and its derivatives

Curcumin and its derivatives; curcuminoids have been proven as potential remedies in different diseases. However, their delivery carries several challenges owing to their poor aqueous solubility, photodegradation, chemical instability, poor bioavailability and rapid metabolism. This review explores...

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Bibliographic Details
Published in:Journal of controlled release 2016-03, Vol.225, p.1-30
Main Authors: Mehanny, Mina, Hathout, Rania M., Geneidi, Ahmed S., Mansour, Samar
Format: Article
Language:English
Subjects:
Animals
Curcumin
Curcumin - administration & dosage
Curcumin - analogs & derivatives
Curcuminoids
Drug Carriers - administration & dosage
Drug delivery
Humans
Nanocarriers
Nanoparticles - administration & dosage
Nanotechnology
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Summary:Curcumin and its derivatives; curcuminoids have been proven as potential remedies in different diseases. However, their delivery carries several challenges owing to their poor aqueous solubility, photodegradation, chemical instability, poor bioavailability and rapid metabolism. This review explores and criticizes the numerous attempts that were adopted through the years to entrap/encapsulate this valuable drug in nanocarriers aiming to reach its most appropriate and successful delivery system. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2016.01.018