Biomonitoring of prenatal analgesic intake and correlation with infantile anti‐aeroallergens IgE

An association between prenatal acetaminophen or ibuprofen intake and an increased risk of asthma and increased IgE level in children is discussed in various epidemiological studies. Although the molecular mechanistic link is still unknown, the question whether or not acetaminophen and/or ibuprofen...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2016-06, Vol.71 (6), p.901-906
Main Authors: Hoeke, H., Roeder, S., Mueller, A., Bertsche, T., Borte, M., Rolle‐Kampczyk, U., Bergen, M., Wissenbach, D. K.
Format: Article
Language:English
Subjects:
acetaminophen
Allergens - immunology
Analgesics
Analgesics - adverse effects
Animals
Asthma
Asthma - epidemiology
Asthma - etiology
Breastfeeding & lactation
Female
Humans
IgE
Immunoglobulin E - blood
Immunoglobulin E - immunology
Immunoglobulins
Male
Maternal Exposure - adverse effects
Nonsteroidal anti-inflammatory drugs
Odds Ratio
Pregnancy
prenatal exposure
Risk factors
Seasons
SX1
Time Factors
Citations: Items that this one cites
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Summary:An association between prenatal acetaminophen or ibuprofen intake and an increased risk of asthma and increased IgE level in children is discussed in various epidemiological studies. Although the molecular mechanistic link is still unknown, the question whether or not acetaminophen and/or ibuprofen are safe pain medications during pregnancy arose. In this study, we associate maternal acetaminophen and ibuprofen intake during pregnancy and breastfeeding to infantile asthma phenotypes and elevated IgE level. Therefore, we analysed questionnaires from a local mother–child cohort and monitored drug intake by LC‐MS biomonitoring in urine. No association was found between drug intake and any analysed health outcome using questionnaire data. For the information obtained from biomonitoring, no association was found for ibuprofen and acetaminophen intakes during breastfeeding. However, an association between prenatal acetaminophen intake and increased infantile IgEs related to aeroallergens was statistically detected, but not for asthma phenotypes.
ISSN:0105-4538
1398-9995
DOI:10.1111/all.12897