CRLF2 overexpression identifies an unfavourable subgroup of adult B-cell precursor acute lymphoblastic leukemia lacking recurrent genetic abnormalities

Highlights • 34% of adult B-lineage ALL without aberrations have high CRLF2 expression levels. • In adult B-ALL, CRLF2 expression has prognostic significance. • Also in adult B-ALL, CRLF2 is associated with JAK/STAT and IKZF1 lesions.

Saved in:
Bibliographic Details
Published in:Leukemia research 2016-02, Vol.41, p.36-42
Main Authors: Chiaretti, Sabina, Brugnoletti, Fulvia, Messina, Monica, Paoloni, Francesca, Fedullo, Anna Lucia, Piciocchi, Alfonso, Elia, Loredana, Vitale, Antonella, Mauro, Elisa, Ferrara, Felicetto, De Fabritiis, Paolo, Luppi, Mario, Ronco, Francesca, De Propris, Maria Stefania, Raponi, Sara, Kronnie, Geertruy te, Vignetti, Marco, Guarini, Anna, Foà, Robin
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Adult
Adult patients
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
CRLF2 overexpression
Disease-Free Survival
Female
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology
Prognosis
Proportional Hazards Models
Real-Time Polymerase Chain Reaction
Receptors, Cytokine - biosynthesis
Receptors, Cytokine - genetics
Receptors, Purinergic P2Y - genetics
Recurrence
Reverse Transcriptase Polymerase Chain Reaction
Risk Factors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • 34% of adult B-lineage ALL without aberrations have high CRLF2 expression levels. • In adult B-ALL, CRLF2 expression has prognostic significance. • Also in adult B-ALL, CRLF2 is associated with JAK/STAT and IKZF1 lesions.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2015.11.018