Evaluation of Plasma Melatonin Levels in Children With Afebrile and Febrile Seizures

Abstract Background Melatonin modulates central nervous system neuronal activity. We compared the melatonin levels of patients with febrile and afebrile seizures during and after seizure with those of healthy controls. Methods We enrolled 59 individuals with afebrile and febrile seizures (mean age,...

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Bibliographic Details
Published in:Pediatric neurology 2016-04, Vol.57, p.51-55
Main Authors: Dabak, Orçun, MD, Altun, Demet, MD, Arslan, Mutluay, MD, Yaman, Halil, MD, Vurucu, Sabahattin, MD, Yesilkaya, Ediz, MD, Unay, Bulent, MD
Format: Article
Language:English
Subjects:
Adolescent
antiepileptic
Case-Control Studies
Child
Child, Preschool
Chromatography, High Pressure Liquid
Circadian Rhythm - physiology
epilepsy
febrile seizure
Female
Humans
Infant
Male
melatonin
Melatonin - blood
Neurology
Pediatrics
Seizures - blood
Seizures - classification
Statistics, Nonparametric
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Summary:Abstract Background Melatonin modulates central nervous system neuronal activity. We compared the melatonin levels of patients with febrile and afebrile seizures during and after seizure with those of healthy controls. Methods We enrolled 59 individuals with afebrile and febrile seizures (mean age, 6.09 ± 4.46 years) and 28 age-, sex-, and weight-matched healthy children. Melatonin levels were measured near the time of a seizure (0 to 1 hour) and at 12 and 24 hours post-seizure, and control melatonin levels were measured from a single venous blood sample. Results Plasma melatonin levels increased during seizures in the study group ( P  
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2015.12.025