Suppressive effects of polyozellin on TGFBIp-mediated septic responses in human endothelial cells and mice

Abstract Polyozellus multiplex (Thelephoraceae) is a wild mushroom in Korea and Japan and is usually harvested in early autumn for food. Polyozellin, a major constituent of the edible mushroom Polyozellus multiplex , has been known to exhibit biological activities such as anti-oxidative and anti-inf...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition research (New York, N.Y.) N.Y.), 2016-04, Vol.36 (4), p.380-389
Main Authors: Jung, Byeongjin, Yang, Eun-Ju, Bae, Jong-Sup
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents
Antioxidants
Cecum
Cells, Cultured
Endothelial Cells - drug effects
Endothelial Cells - physiology
Extracellular Matrix Proteins - analysis
Extracellular Matrix Proteins - antagonists & inhibitors
Extracellular Matrix Proteins - pharmacology
Furans - pharmacology
Gastroenterology and Hepatology
Human Umbilical Vein Endothelial Cells
Humans
Ligation
Male
Mice
Mice, Inbred C57BL
Polyozellin
Polyozellus multiplex
Punctures
Sepsis
Sepsis - etiology
Sepsis - prevention & control
Severe inflammation
Signal Transduction
TGFBIp
Transforming Growth Factor beta - analysis
Transforming Growth Factor beta - antagonists & inhibitors
Transforming Growth Factor beta - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Polyozellus multiplex (Thelephoraceae) is a wild mushroom in Korea and Japan and is usually harvested in early autumn for food. Polyozellin, a major constituent of the edible mushroom Polyozellus multiplex , has been known to exhibit biological activities such as anti-oxidative and anti-inflammatory effects. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGF-β. TGFBIp is released by human umbilical vein endothelial cells (HUVECs) and functions as a mediator of experimental sepsis. We hypothesized that polyozellin could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here, we investigated the anti-septic effects and underlying mechanisms of polyozellin against TGFBIp-mediated septic responses. Polyozellin effectively inhibited lipopolysaccharide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, polyozellin suppressed cecal ligation and puncture (CLP)-induced sepsis lethality and pulmonary injury. In conclusion, polyozellin suppressed TGFBIp-mediated and CLP-induced septic responses. Therefore, polyozellin could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway.
ISSN:0271-5317
1879-0739
DOI:10.1016/j.nutres.2015.12.009