Novel inflammatory markers associated with cognitive performance: Singapore Longitudinal Ageing Studies

Abstract We identified and validated several novel inflammatory markers of cognitive performance in community-living older persons. An exploratory study ( n =83) correlated 177 inflammatory markers assayed by Luminex with the Mini-Mental State Examination (MMSE) and identified eight inflammatory mar...

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Bibliographic Details
Published in:Neurobiology of aging 2016-03, Vol.39, p.140-146
Main Authors: Gao, Qi, Camous, Xavier, Lu, Yan-Xia, Lim, May-Li, Larbi, Anis, Ng, Tze-Pin
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Aging - blood
Aging - psychology
Biomarkers - blood
Cognition
Cohort Studies
Cytokine Receptor gp130 - blood
Encephalitis - diagnosis
Encephalitis - psychology
Enzyme-Linked Immunosorbent Assay
Female
High-Throughput Screening Assays
Humans
Inflammation
Interleukin-2 Receptor alpha Subunit - blood
Internal Medicine
Longitudinal Studies
Male
Middle Aged
Neurology
Neuropsychological Tests
sgp130
sIL-2Rα
sTNFR2
TNF Receptor-Associated Factor 2 - blood
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Summary:Abstract We identified and validated several novel inflammatory markers of cognitive performance in community-living older persons. An exploratory study ( n =83) correlated 177 inflammatory markers assayed by Luminex with the Mini-Mental State Examination (MMSE) and identified eight inflammatory markers for ELISA assay and correlations with MMSE, Montreal Cognitive Assessment (MoCA) and cognitive impairment in the validation study ( n =139).The validation study replicated the significant associations of sIL-2Rα ( p =0.050), sTNFR2 ( p =0.002) and sgp130 ( p =0.026) with MMSE and sIL-2Rα ( p =0.019) and sgp130 ( p
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2015.12.002