Infective endocarditis: Clinical presentation, etiology, and early predictors of in-hospital case fatality

We aimed to assess the clinical presentation, microbial etiology and outcome of patients presenting with infective endocarditis (IE). We conducted a four-year retrospective study including all patients presenting with IE. We included 121 patients in the study. The median age was 74.8years. Most pati...

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Bibliographic Details
Published in:Médecine et maladies infectieuses 2016-02, Vol.46 (1), p.44-48
Main Authors: Pilmis, B., Mizrahi, A., Laincer, A., Couzigou, C., El Helali, N., Nguyen Van, J.-C., Abassade, P., Cador, R., Le Monnier, A.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anti-Bacterial Agents - therapeutic use
Cardiac Surgical Procedures - adverse effects
Cardiac Surgical Procedures - utilization
Comorbidity
Diabetes Mellitus - epidemiology
Embolism - epidemiology
Embolism - etiology
Endocardite infectieuse
Endocarditis - drug therapy
Endocarditis - epidemiology
Endocarditis - etiology
Endocarditis - surgery
Epidemiology
Female
France
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation - adverse effects
Heart Valve Prosthesis Implantation - utilization
Hospital Mortality
Humans
Infective endocarditis
Kidney Failure, Chronic - epidemiology
Male
Middle Aged
Postoperative Complications - epidemiology
Postoperative Complications - etiology
Postoperative Complications - therapy
Prognosis
Prosthesis-Related Infections - drug therapy
Prosthesis-Related Infections - epidemiology
Prosthesis-Related Infections - surgery
Retrospective Studies
Staphylococcus aureus
Épidémiologie
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Summary:We aimed to assess the clinical presentation, microbial etiology and outcome of patients presenting with infective endocarditis (IE). We conducted a four-year retrospective study including all patients presenting with IE. We included 121 patients in the study. The median age was 74.8years. Most patients had native valve IE (57%). Staphylococcus aureus accounted for 24.8% of all IE. Surgery was indicated for 70 patients (57.9%) but actually performed in only 55 (44.7%). Factors associated with surgery were younger age (P=0.002) and prosthetic valve IE (P=0.001). Risk factors associated with in-hospital mortality were diabetes mellitus (OR=3.17), chronic renal insufficiency (OR=6.62), and surgical indication (OR=3.49). Mortality of patients who underwent surgery was one sixth of that of patients with surgical indication who did not have the surgery (P
ISSN:0399-077X
1769-6690
DOI:10.1016/j.medmal.2015.12.012