Associations of olfactory bulb and depth of olfactory sulcus with basal ganglia and hippocampus in patients with Parkinson’s disease

•The olfactory bulb (OB) and olfactory sulcus depth (OSD) were significantly atrophic in patients with PD.•Significant correlations between the right OB volume and the left putamen, and between the right OSD and the right hippocampal volume.•Our study is the first to demonstrate associations of olfa...

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Bibliographic Details
Published in:Neuroscience letters 2016-05, Vol.620, p.111-114
Main Authors: Tanik, Nermin, Serin, Halil Ibrahim, Celikbilek, Asuman, Inan, Levent Ertugrul, Gundogdu, Fatma
Format: Article
Language:English
Subjects:
Aged
Basal Ganglia - pathology
Case-Control Studies
Cross-Sectional Studies
Female
Hippocampus
Hippocampus - pathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Olfactory bulb
Olfactory Bulb - pathology
Olfactory sulcus depth
Organ Size
Parkinson Disease - pathology
Parkinson’s disease
Prefrontal Cortex - pathology
Prospective Studies
Putamen
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Summary:•The olfactory bulb (OB) and olfactory sulcus depth (OSD) were significantly atrophic in patients with PD.•Significant correlations between the right OB volume and the left putamen, and between the right OSD and the right hippocampal volume.•Our study is the first to demonstrate associations of olfactory structures with the putamen and hippocampus using MRI volumetric measurements. Parkinson’s disease (PD) is a neurodegenerative disorder characterized by hyposmia in the preclinical stages. We investigated the relationships of olfactory bulb (OB) volume and olfactory sulcus (OS) depth with basal ganglia and hippocampal volumes. The study included 25 patients with PD and 40 age- and sex-matched control subjects. Idiopathic PD was diagnosed according to published diagnostic criteria. The Hoehn and Yahr (HY) scale, the motor subscale of the Unified Parkinson’s Disease Rating Scale (UPDRS III), and the Mini-Mental State Examination (MMSE) were administered to participants. Volumetric measurements of olfactory structures, the basal ganglia, and hippocampus were performed using magnetic resonance imaging (MRI). OB volume and OS depth were significantly reduced in PD patients compared to healthy control subjects (p
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2016.03.050