Potential novel markers to discriminate between active and latent tuberculosis infection in Chinese individuals

Highlights • DosR antigens Rv2029c, Rv2628 or Rv1813c induced a higher proportion of T cells producing IFN-γ from LTBI compared to active TB patients in Chinese populations. • The level of IgG specific for Rv1813c was higher in the TB group than in LTBI and uninfected healthy subjects, but not for R...

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Bibliographic Details
Published in:Comparative immunology, microbiology and infectious diseases microbiology and infectious diseases, 2016-02, Vol.44, p.8-13
Main Authors: Bai, Xue-juan, Liang, Yan, Yang, You-rong, Feng, Jin-dong, Luo, Zhan-peng, Zhang, Jun-xian, Wu, Xue-qiong
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Aged
Allergy and Immunology
Antibodies, Bacterial - blood
Antibodies, Bacterial - immunology
Antigens, Bacterial - blood
Antigens, Bacterial - immunology
Bacterial Proteins - blood
Bacterial Proteins - immunology
BCG Vaccine - immunology
Biomarkers - blood
China - epidemiology
Diagnosis
Enzyme-Linked Immunosorbent Assay
Enzyme-Linked Immunospot Assay
Female
Humans
Immunity, Humoral
Immunoglobulin G - blood
Infectious Disease
Latent Tuberculosis - diagnosis
Latent Tuberculosis - ethnology
Latent Tuberculosis - immunology
Latent Tuberculosis - microbiology
Latent tuberculosis infection
Male
Middle Aged
Mycobacterium
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Prospective Studies
Rv1813c
Rv2029c
Rv2628
T-Lymphocytes - immunology
Tuberculosis
Tuberculosis - diagnosis
Tuberculosis - ethnology
Tuberculosis - immunology
Tuberculosis - microbiology
Young Adult
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Summary:Highlights • DosR antigens Rv2029c, Rv2628 or Rv1813c induced a higher proportion of T cells producing IFN-γ from LTBI compared to active TB patients in Chinese populations. • The level of IgG specific for Rv1813c was higher in the TB group than in LTBI and uninfected healthy subjects, but not for Rv2029c and Rv2628. • BCG vaccination and non-tuberculosis respiratory disease had little influence on the immunological response of Rv2029c and Rv2628. • T cell response to Rv2628 and antibody response to Rv1813c might be applicable as biomarkers to distinguish TB from LTBI and uninfected individuals.
ISSN:0147-9571
1878-1667
DOI:10.1016/j.cimid.2015.11.002