Changes in synaptic plasticity and expression of glutamate receptor subunits in the CA1 and CA3 areas of the hippocampus after transient global ischemia

Highlights • Transient global ischemia induced changes in number of synapses and thickness of PSD in the CA1 area but not CA3 region. • The NR2B/NR2A and GluR1/GluR2 ratios increased in the CA1 area but not CA3 region after ischemia. • Changes in synaptic morphology and glutamate receptor subunits i...

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Bibliographic Details
Published in:Neuroscience 2016-07, Vol.327, p.64-78
Main Authors: Han, Xin-Jia, Shi, Zhong-Shan, Xia, Luo-Xing, Zhu, Li-Hui, Zeng, Ling, Nie, Jun-Hua, Xu, ZaoCheng, Ruan, Yi-Wen
Format: Article
Language:English
Subjects:
Animals
CA1 Region, Hippocampal - metabolism
CA3 Region, Hippocampal - metabolism
Cell Death - physiology
glutamate receptor
Glutamic Acid - metabolism
hippocampus
Ischemic Attack, Transient - metabolism
Male
Neurology
Neuronal Plasticity - physiology
protein expression
Rats, Wistar
Receptors, AMPA - metabolism
Receptors, Glutamate - metabolism
Receptors, N-Methyl-D-Aspartate - metabolism
synapse
Synapses - metabolism
transient global ischemia
ultrastructure
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Summary:Highlights • Transient global ischemia induced changes in number of synapses and thickness of PSD in the CA1 area but not CA3 region. • The NR2B/NR2A and GluR1/GluR2 ratios increased in the CA1 area but not CA3 region after ischemia. • Changes in synaptic morphology and glutamate receptor subunits in the CA1 area may be related to ischemic-neuronal death.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.04.011