Paecilonic acids A and B, bicyclic fatty acids from the jellyfish-derived fungus Paecilomyces variotii J08NF-1

[Display omitted] Two new bicyclic fatty acids, paecilonic acids A and B (1 and 2), were isolated from the culture broth of the marine fungus Paecilomyces variotii derived from the jellyfish Nemopilema nomurai. Compounds 1 and 2 share the same molecular formula and possess a 6,8-dioxabicyclo[3.2.1]o...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2016-05, Vol.26 (9), p.2220-2223
Main Authors: Wang, Haibo, Hong, Jongki, Yin, Jun, Liu, Juan, Liu, Yonghong, Choi, Jae Sue, Jung, Jee H.
Format: Article
Language:English
Subjects:
Animals
Bicyclic fatty acid
Fatty Acids - isolation & purification
Marine fungus
Paecilomyces - chemistry
Paecilomyces variotii
Paecilonic acid
Scyphozoa - chemistry
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Summary:[Display omitted] Two new bicyclic fatty acids, paecilonic acids A and B (1 and 2), were isolated from the culture broth of the marine fungus Paecilomyces variotii derived from the jellyfish Nemopilema nomurai. Compounds 1 and 2 share the same molecular formula and possess a 6,8-dioxabicyclo[3.2.1]octane core skeleton. The planar structures of compounds 1 and 2 were established by spectroscopic analysis, which included NMR and ESI-MS/MS. Relative and absolute configurations were determined by analyzing coupling constants, NOESY correlations, and optical rotations.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2016.03.057