Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques

Highlights • Macaques were implanted with intrathecal catheters for repeated, awake CSF sampling. • Macaques were treated with intranasal and intravenous oxytocin. • Concurrent plasma and CSF samples were taken at five time points after treatment. • Our results extend and partially replicate the fin...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2016-04, Vol.66, p.185-194
Main Authors: Freeman, Sara M, Samineni, Sridhar, Allen, Philip C, Stockinger, Diane, Bales, Karen L, Hwa, Granger G.C, Roberts, Jeffrey A
Format: Article
Language:English
Subjects:
Administration, Intranasal
Administration, Intravenous
Animals
Behavior, Animal - drug effects
Central Nervous System - drug effects
Central Nervous System - metabolism
Cerebrospinal fluid
Cross-Over Studies
ELISA
Endocrinology & Metabolism
Female
Infusions, Intraventricular
Macaca mulatta
Nasal spray
Neuropeptide
Oxytocin - administration & dosage
Oxytocin - blood
Oxytocin - cerebrospinal fluid
Oxytocin - pharmacokinetics
Psychiatry
Random Allocation
Rhesus macaque
Social Behavior
Wakefulness - drug effects
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Summary:Highlights • Macaques were implanted with intrathecal catheters for repeated, awake CSF sampling. • Macaques were treated with intranasal and intravenous oxytocin. • Concurrent plasma and CSF samples were taken at five time points after treatment. • Our results extend and partially replicate the findings of similar studies. • We highlight the importance of methodological consistency across oxytocin studies.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.01.014