Antioxidative–oxidative balance in epilepsy patients on antiepileptic therapy: a prospective case–control study

Oxidative stress has been implicated in various disorders, including epilepsy. The aim of this study was to investigate the oxidant and antioxidant status of patients with epilepsy using antiepileptic drugs regularly and to compare them with healthy subjects. We investigated serum catalase (CAT), ma...

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Bibliographic Details
Published in:Neurological sciences 2016-05, Vol.37 (5), p.763-767
Main Authors: Keskin Guler, Selda, Aytac, Bilal, Durak, Zahide Esra, Gokce Cokal, Burcu, Gunes, Nalan, Durak, Ilker, Yoldas, Tahir
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Anticonvulsants - therapeutic use
Antioxidants - metabolism
Antioxidants - therapeutic use
Case-Control Studies
Catalase - blood
Epilepsy - blood
Epilepsy - drug therapy
Female
Glutathione Peroxidase - blood
Humans
Male
Malondialdehyde - blood
Medicine
Medicine & Public Health
Middle Aged
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Original Article
Oxidative Stress - drug effects
Prospective Studies
Psychiatry
Superoxide Dismutase - blood
Xanthine Oxidase - blood
Young Adult
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Summary:Oxidative stress has been implicated in various disorders, including epilepsy. The aim of this study was to investigate the oxidant and antioxidant status of patients with epilepsy using antiepileptic drugs regularly and to compare them with healthy subjects. We investigated serum catalase (CAT), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and xanthine oxidase (XO) levels in 58 epilepsy patients and 25 healthy controls. Patients were divided into polytherapy ( n  = 17) and monotherapy ( n  = 41) groups, and antioxidant status was compared between the two groups and controls. There was no significant difference between the patient and control groups in terms of age or gender ( p  > 0.05). The mean duration of illness in the patients was 14.8 years, and the mean duration of treatment was 11.4 years. Comparison of the patient and control groups in terms of oxidative stress and antioxidant defence parameters revealed significantly higher MDA, GSH-Px, XO and lower level of CAT, SOD levels ( p  
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-016-2494-0