Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment

Highlights • We report a case of asymptomatic progressive multifocal leukoencephalopathy (PML) detected on regular MRI screening. • The initial MRI detection of PML was both atypical and subtle. • Pre-emptive treatment was associated with a benign PML course and outcome. • Changes on MRI during nata...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2016-03, Vol.25, p.145-147
Main Authors: Fabis-Pedrini, Marzena J, Xu, Wen, Burton, Jason, Carroll, William M, Kermode, Allan G
Format: Article
Language:English
Subjects:
Adult
Humans
Immune reconstitution inflammatory syndrome
Immunologic Factors - adverse effects
JC Virus - immunology
Leukoencephalopathy, Progressive Multifocal - chemically induced
Magnetic Resonance Imaging
Male
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - drug therapy
Natalizumab
Natalizumab - adverse effects
Neurology
Progressive multifocal leukoencephalopathy
Treatment Outcome
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Summary:Highlights • We report a case of asymptomatic progressive multifocal leukoencephalopathy (PML) detected on regular MRI screening. • The initial MRI detection of PML was both atypical and subtle. • Pre-emptive treatment was associated with a benign PML course and outcome. • Changes on MRI during natalizumab treatment may suggest PML as a possible cause.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2015.08.027