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Serum Dioxin and Hepatic Abnormalities in Veterans of Operation Ranch Hand
PURPOSE: We studied hepatic abnormalities and indices of hepatic function in relation to exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in veterans of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of herbicides in Vietnam from 1962 to 1971. METHODS: The preva...
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| Published in: | Annals of epidemiology 2001-07, Vol.11 (5), p.304-311 |
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| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c458t-8530afe2a6140a7be70f6f1c50e4aebe3fd8ea0e8195c0b147e02ebac57252933 |
| container_end_page | 311 |
| container_issue | 5 |
| container_start_page | 304 |
| container_title | Annals of epidemiology |
| container_volume | 11 |
| creator | Michalek, Joel E Ketchum, Norma S Longnecker, Matthew P |
| description | PURPOSE: We studied hepatic abnormalities and indices of hepatic function in relation to exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in veterans of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of herbicides in Vietnam from 1962 to 1971.
METHODS: The prevalence of ever having liver disease through March 1993, and level of alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase (GGT), lactic dehydrogenase (LDH), alkaline phosphatase, and total bilirubin were examined according to serum dioxin levels.
RESULTS: We found an increased risk of “other liver disorders” among veterans with the highest dioxin levels [adjusted odds ratio (OR) = 1.6, 95% confidence interval (CI) 1.2 to 2.1], due primarily to increased transaminases or LDH (adjusted OR = 2.7, 95% CI 1.4 to 5.1) and to other nonspecific liver abnormalities (adjusted OR = 1.4, 95% CI 1.0 to 2.0).
CONCLUSIONS: Whether the associations observed were causal is unclear from these data. |
| doi_str_mv | 10.1016/S1047-2797(00)00218-0 |
| format | article |
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METHODS: The prevalence of ever having liver disease through March 1993, and level of alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase (GGT), lactic dehydrogenase (LDH), alkaline phosphatase, and total bilirubin were examined according to serum dioxin levels.
RESULTS: We found an increased risk of “other liver disorders” among veterans with the highest dioxin levels [adjusted odds ratio (OR) = 1.6, 95% confidence interval (CI) 1.2 to 2.1], due primarily to increased transaminases or LDH (adjusted OR = 2.7, 95% CI 1.4 to 5.1) and to other nonspecific liver abnormalities (adjusted OR = 1.4, 95% CI 1.0 to 2.0).
CONCLUSIONS: Whether the associations observed were causal is unclear from these data.</description><identifier>ISSN: 1047-2797</identifier><identifier>EISSN: 1873-2585</identifier><identifier>DOI: 10.1016/S1047-2797(00)00218-0</identifier><identifier>PMID: 11399444</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>2,4,5-Trichlorophenoxyacetic Acid - adverse effects ; 2,4-Dichlorophenoxyacetic Acid - adverse effects ; Aerospace Medicine ; Agent Orange ; Alcohol Drinking - adverse effects ; Chemical and Drug Induced Liver Injury ; Defoliants, Chemical - adverse effects ; Defoliants, Chemical - blood ; Dioxin ; gamma-Glutamyltransferase - blood ; Hepatic Abnormality ; Hepatomegaly - chemically induced ; Hepatomegaly - epidemiology ; Humans ; Liver Diseases - epidemiology ; Liver Function Tests ; Middle Aged ; Odds Ratio ; Polychlorinated Dibenzodioxins - adverse effects ; Polychlorinated Dibenzodioxins - blood ; Prevalence ; Prospective Studies ; Regression Analysis ; Risk ; United States - epidemiology ; Veterans - statistics & numerical data ; Vietnam</subject><ispartof>Annals of epidemiology, 2001-07, Vol.11 (5), p.304-311</ispartof><rights>2001 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-8530afe2a6140a7be70f6f1c50e4aebe3fd8ea0e8195c0b147e02ebac57252933</citedby><cites>FETCH-LOGICAL-c458t-8530afe2a6140a7be70f6f1c50e4aebe3fd8ea0e8195c0b147e02ebac57252933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11399444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Michalek, Joel E</creatorcontrib><creatorcontrib>Ketchum, Norma S</creatorcontrib><creatorcontrib>Longnecker, Matthew P</creatorcontrib><title>Serum Dioxin and Hepatic Abnormalities in Veterans of Operation Ranch Hand</title><title>Annals of epidemiology</title><addtitle>Ann Epidemiol</addtitle><description>PURPOSE: We studied hepatic abnormalities and indices of hepatic function in relation to exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in veterans of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of herbicides in Vietnam from 1962 to 1971.
METHODS: The prevalence of ever having liver disease through March 1993, and level of alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase (GGT), lactic dehydrogenase (LDH), alkaline phosphatase, and total bilirubin were examined according to serum dioxin levels.
RESULTS: We found an increased risk of “other liver disorders” among veterans with the highest dioxin levels [adjusted odds ratio (OR) = 1.6, 95% confidence interval (CI) 1.2 to 2.1], due primarily to increased transaminases or LDH (adjusted OR = 2.7, 95% CI 1.4 to 5.1) and to other nonspecific liver abnormalities (adjusted OR = 1.4, 95% CI 1.0 to 2.0).
CONCLUSIONS: Whether the associations observed were causal is unclear from these data.</description><subject>2,4,5-Trichlorophenoxyacetic Acid - adverse effects</subject><subject>2,4-Dichlorophenoxyacetic Acid - adverse effects</subject><subject>Aerospace Medicine</subject><subject>Agent Orange</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Chemical and Drug Induced Liver Injury</subject><subject>Defoliants, Chemical - adverse effects</subject><subject>Defoliants, Chemical - blood</subject><subject>Dioxin</subject><subject>gamma-Glutamyltransferase - blood</subject><subject>Hepatic Abnormality</subject><subject>Hepatomegaly - chemically induced</subject><subject>Hepatomegaly - epidemiology</subject><subject>Humans</subject><subject>Liver Diseases - epidemiology</subject><subject>Liver Function Tests</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Polychlorinated Dibenzodioxins - adverse effects</subject><subject>Polychlorinated Dibenzodioxins - blood</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Regression Analysis</subject><subject>Risk</subject><subject>United States - epidemiology</subject><subject>Veterans - statistics & numerical data</subject><subject>Vietnam</subject><issn>1047-2797</issn><issn>1873-2585</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkEtPwzAQhC0EolD4CSCfEBwCayeunROqyqOgSpUocLUcZyOMmgd2guDfkz4QR0470s7saD9CThhcMmCjqwWDREZcpvIc4AKAMxXBDjlgSsYRF0rs9vrXMiCHIbwDgFSS75MBY3GaJklyQB4X6LuS3rj6y1XUVDmdYmNaZ-k4q2pfmqVrHQbaL1-xRW-qQOuCzptetq6u6JOp7Bud9skjsleYZcDj7RySl7vb58k0ms3vHybjWWQTodpIiRhMgdyMWAJGZiihGBXMCsDEYIZxkSs0gIqlwkLGEonAMTNWSC54GsdDcra52_j6o8PQ6tIFi8ulqbDugmYyZYz3NUMiNkbr6xA8FrrxrjT-WzPQK4h6DVGvCGkAvYaooc-dbgu6rMT8L7Wl1huuNwbs3_x06HWwDiuLufNoW53X7p-KH23TgNA</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Michalek, Joel E</creator><creator>Ketchum, Norma S</creator><creator>Longnecker, Matthew P</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20010701</creationdate><title>Serum Dioxin and Hepatic Abnormalities in Veterans of Operation Ranch Hand</title><author>Michalek, Joel E ; Ketchum, Norma S ; Longnecker, Matthew P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-8530afe2a6140a7be70f6f1c50e4aebe3fd8ea0e8195c0b147e02ebac57252933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>2,4,5-Trichlorophenoxyacetic Acid - adverse effects</topic><topic>2,4-Dichlorophenoxyacetic Acid - adverse effects</topic><topic>Aerospace Medicine</topic><topic>Agent Orange</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Chemical and Drug Induced Liver Injury</topic><topic>Defoliants, Chemical - adverse effects</topic><topic>Defoliants, Chemical - blood</topic><topic>Dioxin</topic><topic>gamma-Glutamyltransferase - blood</topic><topic>Hepatic Abnormality</topic><topic>Hepatomegaly - chemically induced</topic><topic>Hepatomegaly - epidemiology</topic><topic>Humans</topic><topic>Liver Diseases - epidemiology</topic><topic>Liver Function Tests</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Polychlorinated Dibenzodioxins - adverse effects</topic><topic>Polychlorinated Dibenzodioxins - blood</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Regression Analysis</topic><topic>Risk</topic><topic>United States - epidemiology</topic><topic>Veterans - statistics & numerical data</topic><topic>Vietnam</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Michalek, Joel E</creatorcontrib><creatorcontrib>Ketchum, Norma S</creatorcontrib><creatorcontrib>Longnecker, Matthew P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Annals of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Michalek, Joel E</au><au>Ketchum, Norma S</au><au>Longnecker, Matthew P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Dioxin and Hepatic Abnormalities in Veterans of Operation Ranch Hand</atitle><jtitle>Annals of epidemiology</jtitle><addtitle>Ann Epidemiol</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>11</volume><issue>5</issue><spage>304</spage><epage>311</epage><pages>304-311</pages><issn>1047-2797</issn><eissn>1873-2585</eissn><abstract>PURPOSE: We studied hepatic abnormalities and indices of hepatic function in relation to exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in veterans of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of herbicides in Vietnam from 1962 to 1971.
METHODS: The prevalence of ever having liver disease through March 1993, and level of alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase (GGT), lactic dehydrogenase (LDH), alkaline phosphatase, and total bilirubin were examined according to serum dioxin levels.
RESULTS: We found an increased risk of “other liver disorders” among veterans with the highest dioxin levels [adjusted odds ratio (OR) = 1.6, 95% confidence interval (CI) 1.2 to 2.1], due primarily to increased transaminases or LDH (adjusted OR = 2.7, 95% CI 1.4 to 5.1) and to other nonspecific liver abnormalities (adjusted OR = 1.4, 95% CI 1.0 to 2.0).
CONCLUSIONS: Whether the associations observed were causal is unclear from these data.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11399444</pmid><doi>10.1016/S1047-2797(00)00218-0</doi><tpages>8</tpages></addata></record> |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | 2,4,5-Trichlorophenoxyacetic Acid - adverse effects 2,4-Dichlorophenoxyacetic Acid - adverse effects Aerospace Medicine Agent Orange Alcohol Drinking - adverse effects Chemical and Drug Induced Liver Injury Defoliants, Chemical - adverse effects Defoliants, Chemical - blood Dioxin gamma-Glutamyltransferase - blood Hepatic Abnormality Hepatomegaly - chemically induced Hepatomegaly - epidemiology Humans Liver Diseases - epidemiology Liver Function Tests Middle Aged Odds Ratio Polychlorinated Dibenzodioxins - adverse effects Polychlorinated Dibenzodioxins - blood Prevalence Prospective Studies Regression Analysis Risk United States - epidemiology Veterans - statistics & numerical data Vietnam |
| title | Serum Dioxin and Hepatic Abnormalities in Veterans of Operation Ranch Hand |
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