The predictive value of the antioxidative function of HDL for cardiovascular disease and graft failure in renal transplant recipients

• Published in: Atherosclerosis 2016-06, Vol.249, p.181-185
• Main Authors: Leberkühne, Lynn J, Ebtehaj, Sanam, Dimova, Lidiya G, Dikkers, Arne, Dullaart, Robin P.F, Bakker, Stephan J.L, Tietge, Uwe J.F
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antioxidants - metabolism; Atherosclerosis; Cardiovascular; Cardiovascular Diseases - complications; Cardiovascular Diseases - metabolism; Female; Follow-Up Studies; Glomerular Filtration Rate; Graft Survival; HDL; HDL function; Humans; Inflammation; Kidney - physiopathology; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - surgery; Kidney Transplantation; Lipoproteins, HDL - metabolism; Male; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Prospective study; Surveys and Questionnaires; Transplant Recipients
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2016.04.008

Abstract Background Protection of low-density lipoproteins (LDL) against oxidative modification is a key anti-atherosclerotic property of high-density lipoproteins (HDL). This study evaluated the predictive value of the HDL antioxidative function for cardiovascular mortality, all-cause mortality and chronic graft failure in renal transplant recipients (RTR). Methods The capacity of HDL to inhibit native LDL oxidation was determined in vitro in a prospective cohort of renal transplant recipients (RTR, n = 495, median follow-up 7.0 years). Results The HDL antioxidative functionality was significantly higher in patients experiencing graft failure (57.4 ± 9.7%) than in those without (54.2 ± 11.3%; P  = 0.039), while there were no differences for cardiovascular and all-cause mortality. Specifically glomerular filtration rate ( P  = 0.001) and C-reactive protein levels ( P  = 0.006) associated independently with antioxidative functionality in multivariate linear regression analyses. Cox regression analysis demonstrated a significant relationship between antioxidative functionality of HDL and graft failure in age-adjusted analyses, but significance was lost following adjustment for baseline kidney function and inflammatory load. No significant association was found between HDL antioxidative functionality and cardiovascular and all-cause mortality. Conclusion This study demonstrates that the antioxidative function of HDL (i) does not predict cardiovascular or all-cause mortality in RTR, but (ii) conceivably contributes to the development of graft failure, however, not independent of baseline kidney function and inflammatory load.