Phosphate binders in chronic kidney disease: a systematic review of recent data

Hyperphosphatemia is common in chronic kidney disease (CKD) and is treated by dietary measures, dialysis techniques and/or phosphate binders. For the present review PubMed was searched for new publications on phosphate binders appearing between January 2010 and October 2015. This review summarizes t...

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Bibliographic Details
Published in:Journal of nephrology 2016-06, Vol.29 (3), p.329-340
Main Author: Floege, Jürgen
Format: Article
Language:English
Subjects:
Drug Combinations
Ferric Compounds - therapeutic use
Humans
Hyperphosphatemia - drug therapy
Lanthanum - therapeutic use
Medicine
Medicine & Public Health
Nephrology
Phosphates - metabolism
Polyamines - therapeutic use
Renal Insufficiency, Chronic - drug therapy
Review
Sevelamer - therapeutic use
Sucrose - therapeutic use
Urology
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Summary:Hyperphosphatemia is common in chronic kidney disease (CKD) and is treated by dietary measures, dialysis techniques and/or phosphate binders. For the present review PubMed was searched for new publications on phosphate binders appearing between January 2010 and October 2015. This review summarizes the latest information on non-pharmacological measures and their problems in lowering phosphate in CKD patients, effects of phosphate binders on morbidity and mortality, adherence to phosphate binder therapy as well as new information on specific aspects of the various phosphate binders on the market: calcium acetate, calcium carbonate, magnesium-containing phosphate binders, polymeric phosphate binders (sevelamer, bixalomer, colestilan), lanthanum carbonate, ferric citrate, sucroferric oxyhydroxide, aluminum-containing phosphate binders, and new compounds in development. The review also briefly covers the emerging field of drugs targeting intestinal phosphate transporters.
ISSN:1121-8428
1724-6059
DOI:10.1007/s40620-016-0266-9