Reduction of uranium transfer by local chelation in simulated wounds in rats

The aim of the paper is to develop a new approach to treat uranium-contaminated wounds. The efficacy of a local uranium chelator, carballylic amido bis phosphonic acid (CAPBP) was assessed using two different uranium compounds. Rats were contaminated by intramuscular injections of uranyl nitrate or...

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Bibliographic Details
Published in:Human & experimental toxicology 2001-05, Vol.20 (5), p.237-241
Main Authors: Houpert, P, Chazell, V, Paquet, F, Bailly, T, Burgada, R, Henge-Napolil, M H
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bone and Bones - chemistry
carballylic amido bisphosphonic acid
Chelating Agents - pharmacology
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Injections, Intramuscular
Kidney - chemistry
Ligands
Male
Miscellaneous
Molecular biophysics
Nitrates
Organophosphonates - pharmacology
Radiation Injuries
Radiation-biomolecule interaction
Rats
Rats, Sprague-Dawley
Tissue Distribution
Toxicology
Uranium
Uranium - metabolism
Uranium - pharmacokinetics
Uranium Compounds - pharmacokinetics
Wounds and Injuries
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Summary:The aim of the paper is to develop a new approach to treat uranium-contaminated wounds. The efficacy of a local uranium chelator, carballylic amido bis phosphonic acid (CAPBP) was assessed using two different uranium compounds. Rats were contaminated by intramuscular injections of uranyl nitrate or an industrial U04 compound to simulate wound contamination. CAPBP was injected intramuscularly (im) or intraperitoneally (ip) at a dosage of 30,umol kg-. In one experiment, the local administration of CAPBP was combined with a systemic administration of ethane-1-hydroxy-1,1-biphosphonate (EHBP). The local CAPBP treatment resulted in increased retention of uranium at the wound site: about 30% for uranyl nitrate or U04 after the first day and about 15% of U04 after the third day. Consequently, it reduced uranium translocation into the blood and deposition in the kidneys and bone. The combined treatment reduced the uranium deposits in the kidneys, bone and carcass to about one-half of those observed in controls 3 days after U04 contamination. The local CAPBP treatment increased the interval of time between contamination and uranium deposit in the target organs. Thus, it can increase the efficacy of nonspecific local treatments or specific systemic treatments. It could be given rapidly through spray or gel after an accident.
ISSN:0960-3271
1477-0903
DOI:10.1191/096032701678227721