Experimental subchronic mycotoxicoses in mice: individual and combined effects of dietary exposure to fumonisins and aflatoxin B1

We have used a murine model of subchronic mycotoxicoses produced by ingestion of mycotoxins. The five groups of animals studied were fed for 30, 60 and 90 days, respectively, with commercial diet (CD), experimental control diet (ECD), experimental with fumonisin B1 diet (EFD) and experimental with m...

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Bibliographic Details
Published in:Food and chemical toxicology 2001-06, Vol.39 (6), p.579-586
Main Authors: Casado, J.M, Theumer, M, Masih, D.T, Chulze, S, Rubinstein, H.R
Format: Article
Language:English
Subjects:
Aflatoxin B1 - administration & dosage
Aflatoxin B1 - toxicity
Alkaline Phosphatase - blood
Animal Feed
Animals
Aspartate Aminotransferases - blood
Biological and medical sciences
Body Weight - drug effects
Calcium - blood
Carboxylic Acids - administration & dosage
Carboxylic Acids - toxicity
Cholesterol - blood
Disease Models, Animal
Eating - drug effects
Food Contamination
Fumonisin
Fumonisins
Intestine, Small - drug effects
Intestine, Small - pathology
Liver - drug effects
Liver - pathology
Male
Medical sciences
Mice
Mycotoxicosis - etiology
Mycotoxin
Plant poisons toxicology
Subchronic mycotoxicoses
Toxicology
Triglycerides - blood
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Summary:We have used a murine model of subchronic mycotoxicoses produced by ingestion of mycotoxins. The five groups of animals studied were fed for 30, 60 and 90 days, respectively, with commercial diet (CD), experimental control diet (ECD), experimental with fumonisin B1 diet (EFD) and experimental with mixtures of mycotoxins diet (EMD). The animals fed EFD and EMD showed a significant increase in feed consumption/day with respect to the animals fed ECD ( P
ISSN:0278-6915
1873-6351
DOI:10.1016/S0278-6915(00)00174-5