Intra-strain dioxin sensitivity and morphometric effects in swim-up rainbow trout ( Oncorhynchus mykiss)

Inter and intra-specific differences in sensitivity of early life stage salmonids to 2,3,7,8-TCDD exposure have been reported, but intra-strain differences have not been found in the literature. Our results indicate that intra-strain variability in terms of embryo mortality (LD50) is small in Eagle...

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Bibliographic Details
Published in:Comparative biochemistry and physiology. Toxicology & pharmacology 2004-02, Vol.137 (2), p.133-142
Main Authors: Carvalho, Paulo S.M., Noltie, Douglas B., Tillitt, Donald E.
Format: Article
Language:English
Subjects:
Animals
Dioxin
Dose-Response Relationship, Drug
Edema
Edema - chemically induced
Edema - mortality
Female
Freshwater
Growth
Lethal Dose 50
Lethality
Liver Glycogen - metabolism
Oncorhynchus mykiss
Oncorhynchus mykiss - anatomy & histology
Oncorhynchus mykiss - embryology
Oncorhynchus mykiss - growth & development
Polychlorinated Dibenzodioxins - pharmacology
Rainbow trout
Sensitivity
Species Specificity
Swimming - physiology
Wasting syndrome
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Summary:Inter and intra-specific differences in sensitivity of early life stage salmonids to 2,3,7,8-TCDD exposure have been reported, but intra-strain differences have not been found in the literature. Our results indicate that intra-strain variability in terms of embryo mortality (LD50) is small in Eagle Lake strain of rainbow trout, LD50 values ranging from 285 to 457 pg TCDD egg g −1. These results confirm Eagle Lake as a less sensitive strain within rainbow trout, and do not indicate overlap with reported LD50 values for brook or lake trout. Our results also demonstrate that although generalized edema in regions including the yolk-sac are frequently associated with mortality following dioxin exposure, not all edematous fish die. We detected dose-dependent decreases in cranial length, eye diameter, mass, and total length ( P
ISSN:1532-0456
1878-1659
DOI:10.1016/j.cca.2003.12.005