Effects of Ozone Therapy on the Early Healing Period of Deepithelialized Gingival Grafts: A Randomized Placebo‐Controlled Clinical Trial

Background: This study evaluates the effects of ozone therapy (OT) on the early healing period of deepithelialized gingival grafts (DGG) placed for non‐root coverage gingival augmentation by laser Doppler flowmetry (LDF). Methods: Thirty‐three patients were assigned to study groups: 1) test: DGG + O...

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Bibliographic Details
Published in:Journal of periodontology (1970) 2016-06, Vol.87 (6), p.663-671
Main Authors: Taşdemir, Zekeriya, Alkan, Banu Arzu, Albayrak, Haydar
Format: Article
Language:English
Subjects:
Autografts
Dentistry
Gingiva - transplantation
Gingival Diseases - therapy
Humans
Ozone - therapeutic use
pain
Pain, Postoperative
Quality of Life
transplants
Wound Healing
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Summary:Background: This study evaluates the effects of ozone therapy (OT) on the early healing period of deepithelialized gingival grafts (DGG) placed for non‐root coverage gingival augmentation by laser Doppler flowmetry (LDF). Methods: Thirty‐three patients were assigned to study groups: 1) test: DGG + OT; or 2) control group: DGG alone. Thirty patients completed the study. Ozone was applied on DGGs placed in the recipient bed and donor site immediately after surgery and at days 1 and 3 post‐surgery. Blood perfusion in the recipient site was measured by LDF on the day of surgery and at 1, 2, 3, 6, 8, 10, and 13 days after surgery. Quality of life (assessed by the Oral Health Impact Profile‐14) and pain at donor/recipient sites (assessed by visual analog scale) were also investigated. Results: Increase in blood perfusion units in the test group was significantly higher than control group at 1, 2, 3, 6, and 8 days post‐surgery (P
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2016.150217