Prenatal risk factors for depression: a critical review of the evidence and potential mechanisms

Exposure to adverse experiences in early life increases the risk of depression during adulthood. Recent findings have highlighted that exposure of a fetus to an adverse intrauterine environment may also have implications for later offspring depression. This review considers the status of the evidenc...

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Published in:Journal of developmental origins of health and disease 2014-10, Vol.5 (5), p.339-350
Main Authors: Braithwaite, E. C., Murphy, S. E., Ramchandani, P. G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Alcohol Drinking - adverse effects
Anxiety
Babies
Birth weight
Brain research
Cannabis - adverse effects
Cardiovascular disease
Child
Cytokines
Depression - epidemiology
Depression - genetics
Diabetes
Female
Fetuses
Genetic Predisposition to Disease
Humans
Hypotheses
Immune system
Malnutrition - complications
Maternal Health
Mental depression
Middle Aged
Pregnancy
Pregnancy Complications - psychology
Prenatal Exposure Delayed Effects
Review
Risk Factors
Stress
Stress, Psychological - complications
Studies
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description Exposure to adverse experiences in early life increases the risk of depression during adulthood. Recent findings have highlighted that exposure of a fetus to an adverse intrauterine environment may also have implications for later offspring depression. This review considers the status of the evidence for these associations and the potential mechanisms underlying prenatal developmental risks for later depression, addressing the challenging possibility that environmental predisposition to depression may begin before birth.
doi_str_mv 10.1017/S2040174414000324
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source Cambridge Journals Online
subjects Adolescent
Adult
Adults
Alcohol Drinking - adverse effects
Anxiety
Babies
Birth weight
Brain research
Cannabis - adverse effects
Cardiovascular disease
Child
Cytokines
Depression - epidemiology
Depression - genetics
Diabetes
Female
Fetuses
Genetic Predisposition to Disease
Humans
Hypotheses
Immune system
Malnutrition - complications
Maternal Health
Mental depression
Middle Aged
Pregnancy
Pregnancy Complications - psychology
Prenatal Exposure Delayed Effects
Review
Risk Factors
Stress
Stress, Psychological - complications
Studies
title Prenatal risk factors for depression: a critical review of the evidence and potential mechanisms
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