High-Sensitivity Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Prediction of Outcome in Congenital Diaphragmatic Hernia: Results from a Multicenter, Randomized Controlled Trial

Biomarkers may be helpful in prediction of outcomes of infants with congenital diaphragmatic hernia. The predictive value of high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide was investigated in 128 infants with congenital diaphragmatic hernia. After correction for multiple te...

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Bibliographic Details
Published in:The Journal of pediatrics 2016-06, Vol.173, p.245-249.e4
Main Authors: Snoek, Kitty G., MD, Kraemer, Ulrike S., MD, ten Kate, Chantal A., Bsc, Greenough, Anne, MD, van Heijst, Arno, MD, PhD, Capolupo, Irma, MD, PhD, Schaible, Thomas, MD, PhD, van Rosmalen, Joost, PhD, Wijnen, René M., MD, PhD, Reiss, Irwin K.M., MD, PhD, Tibboel, Dick, MD, PhD
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers - blood
Bronchopulmonary Dysplasia - epidemiology
Extracorporeal Membrane Oxygenation - utilization
Female
Hernias, Diaphragmatic, Congenital - mortality
Hernias, Diaphragmatic, Congenital - surgery
Humans
Hypertension, Pulmonary - epidemiology
Infant, Newborn
Male
Natriuretic Peptide, Brain - blood
Netherlands - epidemiology
Pediatrics
Prognosis
Prospective Studies
pulmonary hypertension
Severity of Illness Index
Troponin T - blood
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Summary:Biomarkers may be helpful in prediction of outcomes of infants with congenital diaphragmatic hernia. The predictive value of high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide was investigated in 128 infants with congenital diaphragmatic hernia. After correction for multiple testing, those biomarkers did not predict severe pulmonary hypertension, death, need of extracorporeal membrane oxygenation, or bronchopulmonary dysplasia. Trial registration Netherlands Trial Registry: 1310.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2016.03.026