Virucidal activity of essential oils from aromatic plants of San Luis, Argentina

Essential oils obtained from eight aromatic plants of San Luis Province, Argentina, were screened for virucidal activity against herpes simplex virus type 1 (HSV‐1), Junin virus (JUNV) and dengue virus type 2 (DEN‐2). The most potent inhibition was observed with the essential oil of Lippia junellian...

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Bibliographic Details
Published in:Phytotherapy research 2003-11, Vol.17 (9), p.1073-1075
Main Authors: García, C. C., Talarico, L., Almeida, N., Colombres, S., Duschatzky, C., Damonte, E. B.
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - administration & dosage
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Argentinian plants
Biological and medical sciences
Cercopithecus aethiops
dengue virus
Dengue Virus - drug effects
Dengue virus type 2
Dose-Response Relationship, Drug
essential oils
Flowers
Fruit
General pharmacology
herpes simplex virus
Herpes simplex virus 1
Herpesvirus 1, Human - drug effects
Humans
Inhibitory Concentration 50
Junin virus
Junin virus - drug effects
Medical sciences
Microbial Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Leaves
Plant Oils - administration & dosage
Plant Oils - pharmacology
Plant Oils - therapeutic use
Plants, Medicinal
Temperature
Vero Cells - drug effects
virucidal activity
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Summary:Essential oils obtained from eight aromatic plants of San Luis Province, Argentina, were screened for virucidal activity against herpes simplex virus type 1 (HSV‐1), Junin virus (JUNV) and dengue virus type 2 (DEN‐2). The most potent inhibition was observed with the essential oil of Lippia junelliana and Lippia turbinata against JUNV with virucidal concentration 50% (VC50) values in the range 14–20 ppm, whereas Aloysia gratissima, Heterotheca latifolia and Tessaria absinthioides inhibited JUNV in the range 52–90 ppm. The virucidal activity was time‐ and temperature‐dependent. The essential oils of A. gratissima, Artemisia douglasiana, Eupatorium patens and T. absinthioides inactivated HSV‐1 at 65–125 ppm. However, only A. douglasiana and E. patens had any discernible effect on DEN‐2 infectivity with VC50 values of 60 and 150 ppm, respectively. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1305