Epstein-Barr virus reactivation is induced, but abortive, in cutaneous lesions of systemic hydroa vacciniforme and hypersensitivity to mosquito bites

Highlights • EBV reactivation occurs in the cutaneous lesions of hydroa vacciniforme (HV) and hypersensitivity to mosquito bites (HMB), but seldom in blood. • The down-stream signals of EBV reactivation occurred frequently in EBV+ epithelial neoplasm. • Unlike the in vitro study, the reactivation ca...

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Bibliographic Details
Published in:Journal of dermatological science 2016-06, Vol.82 (3), p.153-159
Main Authors: Yamamoto, Takenobu, Hirai, Yoji, Miyake, Tomoko, Hamada, Toshihisa, Yamasaki, Osamu, Morizane, Shin, Fujimoto, Wataru, Keiji, Iwatsuki
Format: Article
Language:English
Subjects:
Animals
Antigens, Viral - blood
Antigens, Viral - immunology
BDRF1
BZLF1
Capsid Proteins - blood
Capsid Proteins - immunology
Culicidae
Dermatology
Epstein-Barr virus
Herpesvirus 4, Human - isolation & purification
Herpesvirus 4, Human - physiology
Humans
Hydroa vacciniforme
Hydroa Vacciniforme - immunology
Hydroa Vacciniforme - virology
Hypersensitivity - etiology
Hypersensitivity to mosquito bites
Insect Bites and Stings - complications
Insect Bites and Stings - immunology
Killer Cells, Natural - immunology
Lymphoproliferative Disorders - immunology
RNA, Messenger - analysis
RNA, Viral - analysis
Trans-Activators - analysis
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Summary:Highlights • EBV reactivation occurs in the cutaneous lesions of hydroa vacciniforme (HV) and hypersensitivity to mosquito bites (HMB), but seldom in blood. • The down-stream signals of EBV reactivation occurred frequently in EBV+ epithelial neoplasm. • Unlike the in vitro study, the reactivation cascade of HV and HMB is usually abortive in the cutaneous lesions probably because of host immune responses.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2016.03.001