Neuropsychological, electrophysiological and neurological impairments in patients with obsessive compulsive disorder, their healthy siblings and healthy controls: Identifying potential endophenotype(s)

Abstract The etiology of obsessive-compulsive disorder (OCD) has not been clarified. This study aimed to investigate the cognitive, neurological, electrophysiological functions which are reflected in executive functions, memory, visuospatial integration; neurological examination and auditory event r...

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Bibliographic Details
Published in:Psychiatry research 2016-06, Vol.240, p.110-117
Main Authors: Ozcan, Halil, Ozer, Suzan, Yagcioglu, Suha
Format: Article
Language:English
Subjects:
Adult
AERP
Case-Control Studies
Cognition - physiology
Cognition Disorders - genetics
Cognition Disorders - psychology
Cognitive functions
Endophenotype
Endophenotypes
Evoked Potentials, Auditory
Executive Function - physiology
Female
Humans
Male
Memory - physiology
Middle Aged
Neurologic Examination
Neurological soft signs
Neuropsychological Tests
Obsessive-Compulsive Disorder - genetics
Obsessive-Compulsive Disorder - psychology
OCD
P300
Psychiatry
Siblings
Socioeconomic Factors
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Summary:Abstract The etiology of obsessive-compulsive disorder (OCD) has not been clarified. This study aimed to investigate the cognitive, neurological, electrophysiological functions which are reflected in executive functions, memory, visuospatial integration; neurological examination and auditory event related potentials (AERP) (N100, N200, P200 and P300) in patients with OCD, their siblings, and control subjects and to determine potential endophenotypic markers. Thirty-three patients with OCD, 18 siblings and 21 controls; matched for age, gender and years of education were included. Yale Brown Obsessive Compulsive Symptoms Checklist Scale, Hamilton Depression-Rating Scale, an exhaustive neuropscyhological test battery and Neurological Evaluation Scale were administered. Their AERP recordings were obtained. Executive functions and visuospatial integration were highly impaired in patients and slightly in their siblings compared to controls. P200 amplitude was sorted as siblings>patients>controls. P300 amplitude was sorted as patients
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2016.04.013